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INTEGRATIVE ANALYSIS OF MORINGA OLEIFERA PHYTOCHEMICAL COMPOSITION: INSIGHTS FROM LCMS/MS, HPTLC, HPLC PROFILING AND MOLECULAR DOCKING STUDIES

By: Contributor(s): Description: P.53-62Subject(s): DDC classification:
  • P.53-62
 In: Indian Drugs Mumbai Indian Drugs Manufacturer's AssociationSummary: This research presents a comprehensive investigation into the phytochemical composition of Moringa oleifera utilizing LCMS/MS, HPTLC, HPLC profiling and molecular docking studies. LCMS/MS analysis identified 10 key phytocompounds, including β-carbolines, octadecadiynoic acid and quercetin. HPLC technique quantified the presence of quercetin and kaempferol, gallic acid and caffeic acid. Molecular docking studies, conducted using CBDock2, unveiled potential interactions between these compounds and specific target proteins, such as β-glucosidase (PDB ID: 2ZOX). The docking results indicated favourable binding affinities for quercetin-3-O-glucoside, quercetin and kaempferol, highlighting their potential bioactivity.
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Item type Current library Call number Vol info Status Barcode
Journal Article SNDT Juhu P.53-62 (Browse shelf(Opens below)) Available JP287.5
Periodicals SNDT Juhu P 615.8805/ID (Browse shelf(Opens below)) Vol. 61, No. 6 (01/06/2024) Available JP287

This research presents a comprehensive investigation into the phytochemical composition of Moringa oleifera utilizing LCMS/MS, HPTLC, HPLC profiling and molecular docking studies. LCMS/MS analysis identified 10 key phytocompounds, including β-carbolines, octadecadiynoic acid and quercetin. HPLC technique quantified the presence of quercetin and kaempferol, gallic acid and caffeic acid. Molecular docking studies, conducted using CBDock2, unveiled potential interactions between these compounds and specific target proteins, such as β-glucosidase (PDB ID: 2ZOX). The docking results indicated favourable binding affinities for quercetin-3-O-glucoside, quercetin and kaempferol, highlighting their potential bioactivity.

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