SNDT WOMEN'S UNIVERSITY
BMK Knowledge Resource Centre
Vithaldas Vidyavihar, Juhu Tara Road,
Santacruz (West) Mumbai - 400049
FORMULATION AND EVALUATION OF NANOSTRUCTURED LIPID CARRIERS BASED CAPSULE
Karan K. Lokhande
FORMULATION AND EVALUATION OF NANOSTRUCTURED LIPID CARRIERS BASED CAPSULE - P.49-58
The objective of this investigation was to formulate an ideal nanostructured lipid carrier (NLC) for glibenclamide in oral capsules. Employing factorial design, the NLC formulation was achieved through high-pressure homogenization using Design-Expert® software, optimized using a 32 -factor experimental design and response surface analysis. Comprehensive analyses were conducted to characterize NLCs and determine the optimal formulation. Rigorous evaluations, including drug content, in vitro diffusion and stability studies, were performed. Safety assessments, efficacy studies and optimization led to the identification of an optimal NLC formulation with specific lipid and surfactant percentages, resulting in a desirable particle size (nm) and a robust zeta potential indicative of strong physical stability.
Nanostructured lipid carriers
glibenclamide
lipid nanoparticles
capsule
diabetes
factorial design
/ P.49-58
FORMULATION AND EVALUATION OF NANOSTRUCTURED LIPID CARRIERS BASED CAPSULE - P.49-58
The objective of this investigation was to formulate an ideal nanostructured lipid carrier (NLC) for glibenclamide in oral capsules. Employing factorial design, the NLC formulation was achieved through high-pressure homogenization using Design-Expert® software, optimized using a 32 -factor experimental design and response surface analysis. Comprehensive analyses were conducted to characterize NLCs and determine the optimal formulation. Rigorous evaluations, including drug content, in vitro diffusion and stability studies, were performed. Safety assessments, efficacy studies and optimization led to the identification of an optimal NLC formulation with specific lipid and surfactant percentages, resulting in a desirable particle size (nm) and a robust zeta potential indicative of strong physical stability.
Nanostructured lipid carriers
glibenclamide
lipid nanoparticles
capsule
diabetes
factorial design
/ P.49-58