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FORMULATION AND EVALUATION OF β-SITOSTEROL LOADED NIOSOMES FOR ENHANCED ANTIDIABETIC ACTIVITY: A POTENTIAL ALTERNATIVE IN TYPE 2 DIABETES MANAGEMENT
Priya Tiwari
FORMULATION AND EVALUATION OF β-SITOSTEROL LOADED NIOSOMES FOR ENHANCED ANTIDIABETIC ACTIVITY: A POTENTIAL ALTERNATIVE IN TYPE 2 DIABETES MANAGEMENT - P.45-51
Niosomes, vesicles formed by non-ionic surfactants, offer advantages in drug delivery by enhancing solubilization and encapsulating both lipophilic and hydrophilic drugs. This study focuses on β-sitosterol-loaded niosomes designed to protect its anti-diabetic properties. Formulated with Span™ 60, Span™ 80 and cholesterol, the niosomes showed high entrapment efficiency (90%) and favorable release kinetics. Stability studies confirmed their robustness in various conditions. In vivo experiments demonstrated significant improvements in body weight and blood glucose levels in diabetic rats. The optimized formulation (NF8) exhibited controlled release and substantial antidiabetic activity, suggesting its potential as an effective treatment for type 2 diabetes mellitus.
Niosomes
non-ionic surfactants
B-sitosterol
release kinetics
blood glucose level
/ P.45-51
FORMULATION AND EVALUATION OF β-SITOSTEROL LOADED NIOSOMES FOR ENHANCED ANTIDIABETIC ACTIVITY: A POTENTIAL ALTERNATIVE IN TYPE 2 DIABETES MANAGEMENT - P.45-51
Niosomes, vesicles formed by non-ionic surfactants, offer advantages in drug delivery by enhancing solubilization and encapsulating both lipophilic and hydrophilic drugs. This study focuses on β-sitosterol-loaded niosomes designed to protect its anti-diabetic properties. Formulated with Span™ 60, Span™ 80 and cholesterol, the niosomes showed high entrapment efficiency (90%) and favorable release kinetics. Stability studies confirmed their robustness in various conditions. In vivo experiments demonstrated significant improvements in body weight and blood glucose levels in diabetic rats. The optimized formulation (NF8) exhibited controlled release and substantial antidiabetic activity, suggesting its potential as an effective treatment for type 2 diabetes mellitus.
Niosomes
non-ionic surfactants
B-sitosterol
release kinetics
blood glucose level
/ P.45-51