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Clinical evaluation of the safety and therapeutic potential of an Ayurvedic lotion, Ayush AGT, in mild to moderate dandruff- an open-label prospective single-arm multicenter exploratory study
Savita Poshatti Gopod
Clinical evaluation of the safety and therapeutic potential of an Ayurvedic lotion, Ayush AGT, in mild to moderate dandruff- an open-label prospective single-arm multicenter exploratory study - pp717-732
Dandruff is a common skin condition that can significantly impact quality of life. An ideal anti-dandruff treatment should effectively relieve symptoms such as flaking, itching, dryness, and excessive oiliness, while promoting a healthy scalp and encouraging consistent use. This study aimed to clinically evaluate the therapeutic effect and safety of the Ayurvedic lotion Ayush AGT in managing dandruff. The study was conducted at three CCRAS institutes, (RARI Ahmedabad, RARI Vijayawada and CARI Bengaluru) with sample size 150 (50%). Participants with mild to moderate dandruff assessed by mean ASFS across 8 scalp zones with dandruff restricted to scalp were enrolled. Participants were dispensed AYUSH-AGT lotion, and instructed to use lotion every alternate day for 30 days. Outcomes were assessed using ASFS, Quadrant Area Severity Scale and DLQI every 15 days upto 45 days. Pre-post differences were assessed using paired t-test for normally distributed data and Wilcoxon signed-rank test for non-normally distributed data. Data of 143 participants were analyzed and the mean age was 29.29±8.545, with predominantly female distribution. The mean ASFS score significantly decreased from 15.70±4.380 at baseline to 5.41±3.979 at day 30 (p<0.001) and 4.80±4.103 at day 45 (p<0.001), indicating potential clinical effect of Ayush AGT on dandruff severity. QASS scores significantly decreased from 12.78 at baseline to 7.82 (day 15), 4.11 (day 30), and 3.33 (day 45) (p< 0.001). The DLQI score significantly decreased from 7.06±3.923 at baseline to 2.18±2.013 at day 30 (p<0.001), further reducing to 1.85±1.879 at day 45 (p<0.001), indicating reduced impact on daily activities. The study demonstrates that Ayush-AGT is an effective, easy and safe for mild to moderate dandruff.
Ayurveda
Ayush AGT
Dandruff
Darunaka
Herbal lotion
Clinical evaluation of the safety and therapeutic potential of an Ayurvedic lotion, Ayush AGT, in mild to moderate dandruff- an open-label prospective single-arm multicenter exploratory study - pp717-732
Dandruff is a common skin condition that can significantly impact quality of life. An ideal anti-dandruff treatment should effectively relieve symptoms such as flaking, itching, dryness, and excessive oiliness, while promoting a healthy scalp and encouraging consistent use. This study aimed to clinically evaluate the therapeutic effect and safety of the Ayurvedic lotion Ayush AGT in managing dandruff. The study was conducted at three CCRAS institutes, (RARI Ahmedabad, RARI Vijayawada and CARI Bengaluru) with sample size 150 (50%). Participants with mild to moderate dandruff assessed by mean ASFS across 8 scalp zones with dandruff restricted to scalp were enrolled. Participants were dispensed AYUSH-AGT lotion, and instructed to use lotion every alternate day for 30 days. Outcomes were assessed using ASFS, Quadrant Area Severity Scale and DLQI every 15 days upto 45 days. Pre-post differences were assessed using paired t-test for normally distributed data and Wilcoxon signed-rank test for non-normally distributed data. Data of 143 participants were analyzed and the mean age was 29.29±8.545, with predominantly female distribution. The mean ASFS score significantly decreased from 15.70±4.380 at baseline to 5.41±3.979 at day 30 (p<0.001) and 4.80±4.103 at day 45 (p<0.001), indicating potential clinical effect of Ayush AGT on dandruff severity. QASS scores significantly decreased from 12.78 at baseline to 7.82 (day 15), 4.11 (day 30), and 3.33 (day 45) (p< 0.001). The DLQI score significantly decreased from 7.06±3.923 at baseline to 2.18±2.013 at day 30 (p<0.001), further reducing to 1.85±1.879 at day 45 (p<0.001), indicating reduced impact on daily activities. The study demonstrates that Ayush-AGT is an effective, easy and safe for mild to moderate dandruff.
Ayurveda
Ayush AGT
Dandruff
Darunaka
Herbal lotion