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Fabrication and Evaluation of Poloxamer Facilitated, Glyceryl Monooleate based 5-Fluorouracil Cubosomes (Record no. 130060)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02388nam a2200181 4500 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 241107b |||||||| |||| 00| 0 eng d |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Jawaher Abdullah Alamoudi |
| 245 ## - TITLE STATEMENT | |
| Title | Fabrication and Evaluation of Poloxamer Facilitated, Glyceryl Monooleate based 5-Fluorouracil Cubosomes |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | P 91-98 |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. biblio.abstract | Objectives: This study aims to prepare a topical cubosomal formulation that contains 5-Fluorouracil (5-FU), a hydrophilic anti-cancer drug, that belongs to the Biopharmaceutics Classification System (BCS-III) i.e., high solubility and low permeability. Materials and Methods: The 5-FU loaded cubosomes were prepared using Glyceryl Monooleate (GMO) as a lipid polymer, in the presence of Poloxamer 407 (Polox-407) and Tween 80 (T80) as stabilizers. Four formulations of cubosomes were formulated by varying concentrations of Polox-407 and GMO while keeping the concentration of T80 constant. A melting, followed by homogenization technique has been used for the preparation of 5-FU cubosomes. Several In vitro characterization experiments, chemical compatibility studies, pH, viscosity, Scanning Electron Microscopy (SEM), particle size analysis, zeta potential, in vitro drug release studies, in vitro permeation study, and stability studies were performed. Results: The compatibility studies have confirmed the chemical compatibility of the drug and ingredients, while stability analysis has assured that the prepared formulations were stable. Particle size analysis and surface morphology showed that particles were nano-sized with suitable cubical shapes, well segregated from each other. The zeta potential was -0.6 mV and viscosity has been recorded as 18 cP. The drug release and permeation studies revealed that the cumulative amount of the drug was 95% and 94% respectively. Conclusion: Altogether, these findings suggested that upon further optimization, this formulation may have the potential to be translated as an effective therapy for the clinical management of superficial cancers. |
| 654 ## - SUBJECT ADDED ENTRY--FACETED TOPICAL TERMS | |
| Subject | <a href="Cubosomes">Cubosomes</a> |
| -- | <a href=" Permeation"> Permeation</a> |
| -- | <a href="Drug release">Drug release</a> |
| -- | <a href="Thermal analysis.">Thermal analysis.</a> |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Yosif Almoshari |
| -- | Hadil Faris Alotaibi |
| 773 0# - HOST ITEM ENTRY | |
| Host Biblionumber | 125266 |
| Host Itemnumber | 109601 |
| Place, publisher, and date of publication | Banglore Association of Pharmaceutical Tearchers of India |
| Title | Indian Journal of Pharmaceutical Education and Research |
| International Standard Serial Number | 0019-5464 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Koha item type | Journal Article |
| 773 0# - HOST ITEM ENTRY | |
| -- | JP44 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| -- | ddc |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Location (home branch) | Sublocation or collection (holding branch) | Date acquired | Koha issues (times borrowed) | Piece designation (barcode) | Koha date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | SNDT Juhu | SNDT Juhu | 07/11/2024 | JP44.9 | 07/11/2024 | 07/11/2024 | Journal Article |