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Formulation, Optimization and Characterization of PLGA-Chitosan Nanoparticles Containing Vinorelbine Ditartrate (Record no. 130061)
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| 000 -LEADER | |
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| fixed length control field | 01938nam a2200181 4500 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 241107b |||||||| |||| 00| 0 eng d |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Varsha Bandil |
| 245 ## - TITLE STATEMENT | |
| Title | Formulation, Optimization and Characterization of PLGA-Chitosan Nanoparticles Containing Vinorelbine Ditartrate |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | P 99-108 |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. biblio.abstract | Background: The prime objective of our investigation was to optimize PLGA-chitosan nanoparticles containing vinorelbine ditartrate. Materials and Methods: The Vinorelbine ditartrate nanoparticles were formulated using emulsion method followed by probe sonication to reduce the size. A three factor three level Box-Behnken Design has been implemented to optimize chitosan, Poloxamer 188 and sonication time (independent variables) for particle size, polydispersity index and entrapment efficiency (%) as the measured responses. Particle size, zeta potential, surface morphology, entrapment effectiveness, and in vitro drug release were all evaluated for the optimised formulation. Results: The optimized PLGA-chitosan nanoparticle exhibited particles size of 161.22 nm with polydispersity index of 0.229 and zeta potential value of 10.99 mV. The formulation exhibited 78.9% entrapment of vinorelbine ditartrate. The nanoparticle was able to sustain the release of vinorelbine for more than 140 hr in the in vitro release studies. Conclusion: From studying the obtained results, it could be concluded from the investigation that PLGA-chitosan nanoparticles could be good approach to improve the bioavailability of the entrapped drug. |
| 654 ## - SUBJECT ADDED ENTRY--FACETED TOPICAL TERMS | |
| Subject | <a href="Nanoparticles">Nanoparticles</a> |
| -- | <a href="Vinorelbine ditartrate">Vinorelbine ditartrate</a> |
| -- | <a href="Particle size">Particle size</a> |
| -- | <a href=" Optimization"> Optimization</a> |
| -- | <a href="in vitro drug release">in vitro drug release</a> |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Jeetendra Kumar Gupta |
| 773 0# - HOST ITEM ENTRY | |
| Host Biblionumber | 125266 |
| Host Itemnumber | 109601 |
| Place, publisher, and date of publication | Banglore Association of Pharmaceutical Tearchers of India |
| Title | Indian Journal of Pharmaceutical Education and Research |
| International Standard Serial Number | 0019-5464 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Koha item type | Journal Article |
| 773 0# - HOST ITEM ENTRY | |
| -- | JP44 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| -- | ddc |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Location (home branch) | Sublocation or collection (holding branch) | Date acquired | Koha issues (times borrowed) | Piece designation (barcode) | Koha date last seen | Price effective from | Koha item type |
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| Dewey Decimal Classification | SNDT Juhu | SNDT Juhu | 07/11/2024 | jp44.10 | 07/11/2024 | 07/11/2024 | Journal Article |