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Design and Development of Anti-fungal Topical Gel Loaded with Solid Lipid Nanoparticles for Wound Healing (Record no. 130064)
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| 000 -LEADER | |
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| fixed length control field | 02272nam a22001817a 4500 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
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| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Girish Meravanige1 |
| 245 ## - TITLE STATEMENT | |
| Title | Design and Development of Anti-fungal Topical Gel Loaded with Solid Lipid Nanoparticles for Wound Healing |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | p122-130 |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. biblio.abstract | The topical administration of anti-fungal drugs by Solid Lipid Nanoparticles (SLNs) has enormous potential. This study aimed to develop a topical 5-flucytosine-loaded SLNs gel to improve the efficacy of the well-known anti-fungal drug in the treatment of wound healing. Materials and Methods: In order to create 5-flucytosine SLNs, a five-level, two-factor Central-composite design was used. Stearic acid and Poloxamer 407 concentrations of surfactants were chosen as independent factors, and particle size and %Entrapment Efficiency (%EE) were chosen as dependent variables. The produced 5-Flucytosine-SLNs were examined using SEM analysis, zeta potential, polydispersity index, and particle size measurements. Additionally, Carbopol 934 was used to incorporate the improved 5-Flucytosine-SLN formula into gel. Results: The outcomes demonstrated that 5-Flucytosine-SLNs had colloidal sizes with an essentially spherical shape and no aggregation. 5-Flucytosine-SLNs were discovered to have a particle size of 720.4 nm and an Entrapment Efficiency (EE) of 90.28%. The in vitro release, among other assessment criteria, was evaluated for the improved SLN gels. Conclusion: The study's conclusions imply that the topical gels made with 5-Flucytosine-loaded SLNs must be effective in the management of wound healing. |
| 654 ## - SUBJECT ADDED ENTRY--FACETED TOPICAL TERMS | |
| Subject | <a href=" 5-Flucytosine"> 5-Flucytosine</a> |
| -- | <a href="Solid lipid nanoparticle">Solid lipid nanoparticle</a> |
| -- | <a href="Central-composite design">Central-composite design</a> |
| -- | <a href="Topical delivery,">Topical delivery,</a> |
| -- | <a href=" Optimization."> Optimization.</a> |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ranjitha B2 |
| -- | Prakash Goudanavar2 |
| -- | GSN Koteswara Rao3 |
| -- | B Nirmala Devi4 |
| -- | N. Raghavendra Naveen2, |
| -- | Afzal Haq Asif5 |
| -- | Sree Harsha Nagaraja6,7 |
| -- | Mohammed Monirul Islam8 |
| -- | Pavan Kumar |
| -- | Pavagada Sreenivasalu9, |
| -- | , Mallikarjun Telsang10 |
| -- | , Krishna Swaroop Duddi Sreehari1 |
| 773 0# - HOST ITEM ENTRY | |
| Host Biblionumber | 125266 |
| Host Itemnumber | 109601 |
| Place, publisher, and date of publication | Banglore Association of Pharmaceutical Tearchers of India |
| Title | Indian Journal of Pharmaceutical Education and Research |
| International Standard Serial Number | 0019-5464 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Koha item type | Journal Article |
| 773 0# - HOST ITEM ENTRY | |
| -- | JP44 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| -- | ddc |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Location (home branch) | Sublocation or collection (holding branch) | Date acquired | Koha issues (times borrowed) | Piece designation (barcode) | Koha date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | SNDT Juhu | SNDT Juhu | 08/11/2024 | jp.44.13 | 08/11/2024 | 08/11/2024 | Journal Article |