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Amelioration of Lipid Metabolic Profiles by Trigonelline a Bioactive Compound of Trigonella Foenum-graecum in Alcohol Induced Albino Rats (Record no. 130077)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02402nam a2200181 4500 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 241108b |||||||| |||| 00| 0 eng d |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Meesala Guru Sekhar |
| -- | , Kondeti Ramudu Shanmugam2 |
| -- | Kanchi Siva Prasad3 |
| -- | Ramakrishna Chilakala |
| 245 ## - TITLE STATEMENT | |
| Title | Amelioration of Lipid Metabolic Profiles by Trigonelline a Bioactive Compound of Trigonella Foenum-graecum in Alcohol Induced Albino Rats |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | P-172-177 |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. biblio.abstract | : Alcoholism leads to heart diseases, lung diseases and liver disorders. Alcoholism impairs heart homeostasis and causes cardio vascular diseases. The current investigation was carried out to know the hypolipidemic effect of Trigonelline (TG) a bioactive compound of Trigonella foenum-graecum (TGf) in alcohol intoxicated rats. Materials and Methods: The rats were randomized into five groups and treatment was given as per the experimental protocol. The lipid metabolic profiles like Malondialdehyde (MDA), Total Cholesterol (TC), Triglycerides (TGs), High-Density Lipoprotein (HDL), Low-Density Lipoprotein (LDL), Very-Low-Density Lipoprotein (VLDL), and liver markers Alkaline Phosphatase (ALP), Alanine Aminotransferase (AAT), Aspartate Aminotransferase (AST) were estimated in the serum of all experimental groups. Results: All the lipid metabolic profiles and AAT, AST, ALP elevated in alcohol treated group, except HDL. This may be due to the alterations in lipid metabolism, which leads to hypercholesterolaemia and alcohol induced liver damage. Whereas with trigonelline treatment in alcoholic rats, these lipid metabolic profiles and liver markers were normalized and came back to normal levels. Further histopathological observations also proved that trigonelline protected heart tissue from alcohol toxicity in rats. Conclusion: Our findings suggest that trigonelline modulated the lipid metabolic profiles in alcohol intoxicated rats, hence trigonelline might be effective for preventing or treating alcohol related disorders and lipid related diseases. |
| 654 ## - SUBJECT ADDED ENTRY--FACETED TOPICAL TERMS | |
| Subject | <a href=" Alcoholism"> Alcoholism</a> |
| -- | <a href=" Lipid metabolic profiles"> Lipid metabolic profiles</a> |
| -- | <a href="Trigonelline">Trigonelline</a> |
| -- | <a href=" Rats"> Rats</a> |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Kondeti Ramudu Shanmugam |
| -- | Kanchi Siva Prasad3 |
| -- | Ramakrishna Chilakala4 |
| 773 0# - HOST ITEM ENTRY | |
| Host Biblionumber | 125266 |
| Host Itemnumber | 109601 |
| Place, publisher, and date of publication | Banglore Association of Pharmaceutical Tearchers of India |
| Title | Indian Journal of Pharmaceutical Education and Research |
| International Standard Serial Number | 0019-5464 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Koha item type | Journal Article |
| 773 0# - HOST ITEM ENTRY | |
| -- | JP44 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| -- | ddc |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Location (home branch) | Sublocation or collection (holding branch) | Date acquired | Koha issues (times borrowed) | Piece designation (barcode) | Koha date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | SNDT Juhu | SNDT Juhu | 08/11/2024 | JP44.18 | 08/11/2024 | 08/11/2024 | Journal Article |