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NEUROPROTECTIVE POTENTIAL OF HESPERIDIN AGAINST BENZO(A)PYRENE-INDUCED CEREBRAL PALSY (Record no. 130736)
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| 000 -LEADER | |
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| fixed length control field | 01666nam a2200181 4500 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 250114b |||||||| |||| 00| 0 eng d |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Surajit Bhattacharjee |
| 245 ## - TITLE STATEMENT | |
| Title | NEUROPROTECTIVE POTENTIAL OF HESPERIDIN AGAINST BENZO(A)PYRENE-INDUCED CEREBRAL PALSY |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | P.36-44 |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. biblio.abstract | This study investigates the link between cigarette smoke, specifically benzo(a)pyrene (BaP), and cerebral palsy, focusing on BaP’s neurotoxicity. It also examines the neuroprotective potential of hesperidin, a citrus-derived compound, by assessing its binding affinity with the β4 subunit of Adapter Protein Complex 4 (AP-4). Molecular docking analyses using Discovery Studio and PyRx were performed with the β4 subunit of AP-4 as the protein and benzo(a)pyrene and hesperidin as ligands. The results showed that hesperidin had a higher binding affinity (-7.2 kcal mol-1) compared to BaP (-6.5 kcal mol-1), establishing multiple interactions, including van der Waals, hydrogen, and pi-alkyl bonds. Key receptor residues for hesperidin binding were identified. These findings highlight hesperidin’s potential neuroprotective role, suggesting it may help to prevent BaP-induced neurotoxicity in cerebral palsy. The study emphasizes the promise of hesperidin, encouraging further in vivo and clinical investigations. |
| 654 ## - SUBJECT ADDED ENTRY--FACETED TOPICAL TERMS | |
| Subject | <a href="Neuroprotection">Neuroprotection</a> |
| -- | <a href="hesperidin ">hesperidin </a> |
| -- | <a href="benzo(a)pyrene ">benzo(a)pyrene </a> |
| -- | <a href="cerebral palsy">cerebral palsy</a> |
| -- | <a href="molecular docking ">molecular docking </a> |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Shubhadeep Chakraborty |
| 773 0# - HOST ITEM ENTRY | |
| Host Biblionumber | 125265 |
| Host Itemnumber | 111177 |
| Place, publisher, and date of publication | Mumbai Indian Drugs Manufacturer's Association |
| Title | Indian Drugs |
| International Standard Serial Number | 0019-462X |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Koha item type | Journal Article |
| 773 0# - HOST ITEM ENTRY | |
| -- | JP490 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| -- | ddc |
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