SNDT WOMEN'S UNIVERSITY
BMK Knowledge Resource Centre
Vithaldas Vidyavihar, Juhu Tara Road,
Santacruz (West) Mumbai - 400049
DESIGN AND EVALUATION OF SELF-NANOEMULSIFYING DRUG DELIVERY SYSTEM FOR DEFERASIROX (Record no. 130737)
[ view plain ]
| 000 -LEADER | |
|---|---|
| fixed length control field | 01664nam a2200181 4500 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 250114b |||||||| |||| 00| 0 eng d |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Smita A. Lavate |
| 245 ## - TITLE STATEMENT | |
| Title | DESIGN AND EVALUATION OF SELF-NANOEMULSIFYING DRUG DELIVERY SYSTEM FOR DEFERASIROX |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | P.45-56 |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. biblio.abstract | In order to increase deferasirox’s (DEF) solubility and dissolution rate, the study aims to develop a solid self-nanoemulsifying drug delivery system (S-SNEDDS). The impact of concentrations of oil and surfactant on emulsification and in vitro drug release was investigated using an oil, surfactant and cosurfactant mixture. Based on a minimum time of emulsification and a high cumulative percentage of drug dissolution, the formulation F6 was optimized. The optimized formulation showed an emulsification efficiency of 19 ± 0.67 seconds and in vitro drug release of 98.65 ± 0.259 % in 30 minutes. Neusilin® US2 was used to solidify the formulation, which has a high oil adsorption capacity and better micromeritic characters. The analyses of X-ray powder diffraction and differential scanning calorimetry studies displayed the transformation of DEF from its crystalline form to an amorphous form. So, this study demonstrates that the S-SNEDDS is a viable innovative drug delivery strategy for elevating DEF’s solubility and dissolution rate. |
| 654 ## - SUBJECT ADDED ENTRY--FACETED TOPICAL TERMS | |
| Subject | <a href="Deferasirox">Deferasirox</a> |
| -- | <a href="S-SNEDDS">S-SNEDDS</a> |
| -- | <a href="full factorial design ">full factorial design </a> |
| -- | <a href="rate of dissolution">rate of dissolution</a> |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Rohit R. Shah |
| 773 0# - HOST ITEM ENTRY | |
| Host Biblionumber | 125265 |
| Host Itemnumber | 111177 |
| Place, publisher, and date of publication | Mumbai Indian Drugs Manufacturer's Association |
| Title | Indian Drugs |
| International Standard Serial Number | 0019-462X |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Koha item type | Journal Article |
| 773 0# - HOST ITEM ENTRY | |
| -- | JP490 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| -- | ddc |
No items available.