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NOVEL METHOD FOR DETERMINATION OF POMALIDOMIDE IN HUMAN PLASMA BY ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY MASS SPECTROSCOPY / MASS SPECTROSCOPY (Record no. 130738)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 01705nam a2200181 4500 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 250114b |||||||| |||| 00| 0 eng d |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Kalaiselvi Ponnusamy |
| 245 ## - TITLE STATEMENT | |
| Title | NOVEL METHOD FOR DETERMINATION OF POMALIDOMIDE IN HUMAN PLASMA BY ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY MASS SPECTROSCOPY / MASS SPECTROSCOPY |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | P.57-62 |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. biblio.abstract | The current investigation studied and verified an accurate Ultra performance liquid chromatography mass spectroscopy/ mass spectroscopy technique for the high-throughput detection of pomalidomide in human plasma with celecoxib as an internal standard. Chromatographic studies were carried out on Hypersil BDS (50 mm x 4.1 mm, 5m) with an isocratic mobile phase of acetonitrile: ammonium formate (80:20, V/V), at a flow rate of 0.5 mL min-1 and a total run time of 3 min. A triple quadruple Tandem Mass spectroscopy with electrospray ionization in positive mode was utilized to identify the analyte. Using multiple reaction monitoring modes and precursor-to-product ion transitions of 274.43 m/z for pomalidomide and 382.12 m/z for standard, respectively, pomalidomide and internal standard were measured. The developed technique was verified as per the regulatory standards for bioanalytical procedures validation. Other validation results also match. |
| 654 ## - SUBJECT ADDED ENTRY--FACETED TOPICAL TERMS | |
| Subject | <a href="Pomalidomide ">Pomalidomide </a> |
| -- | <a href="lower limit of quantification ">lower limit of quantification </a> |
| -- | <a href="ultra-performance liquid chromatography ">ultra-performance liquid chromatography </a> |
| -- | <a href="celecoxib">celecoxib</a> |
| -- | <a href="bioanalytical ">bioanalytical </a> |
| -- | <a href="matrix stability ">matrix stability </a> |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Kathiravan Natarasan |
| 773 0# - HOST ITEM ENTRY | |
| Host Biblionumber | 125265 |
| Host Itemnumber | 111177 |
| Place, publisher, and date of publication | Mumbai Indian Drugs Manufacturer's Association |
| Title | Indian Drugs |
| International Standard Serial Number | 0019-462X |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Koha item type | Journal Article |
| 773 0# - HOST ITEM ENTRY | |
| -- | JP490 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| -- | ddc |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Location (home branch) | Sublocation or collection (holding branch) | Date acquired | Koha issues (times borrowed) | Piece designation (barcode) | Koha date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | SNDT Juhu | SNDT Juhu | 14/01/2025 | JP490.4 | 14/01/2025 | 14/01/2025 | Journal Article |