SNDT WOMEN'S UNIVERSITY
BMK Knowledge Resource Centre
Vithaldas Vidyavihar, Juhu Tara Road,
Santacruz (West) Mumbai - 400049
DESIGN AND DEVELOPMENT OF INTRA NASAL IN SITU GEL - FORMING NANO STRUCTURED LIPID EMULSIONS OF CURCUMIN FOR BRAIN MALIGNANCIES (Record no. 130759)
[ view plain ]
| 000 -LEADER | |
|---|---|
| fixed length control field | 01663nam a2200181 4500 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 250120b |||||||| |||| 00| 0 eng d |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Koteswari Poluri |
| 245 ## - TITLE STATEMENT | |
| Title | DESIGN AND DEVELOPMENT OF INTRA NASAL IN SITU GEL - FORMING NANO STRUCTURED LIPID EMULSIONS OF CURCUMIN FOR BRAIN MALIGNANCIES |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | P.36-46 |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. biblio.abstract | Glioblastoma Multiforme (GBM), also known as glioblastoma is the most common form of brain tumor. Recent studies have reported that intranasally applied drugs can cross the blood brain barrier and reach the brain directly. In the present investigation, an attempt has been made to prepare curcumin loaded intra nasal in situ gel-forming lipid nanoemulsions to enhance the in vitro and in vivo stability and the availability of curcumin in brain. Nanoemulsion composition was prepared to yield a formulation which was liquid at room temperature and can transform to gel at 37°C. The composition was again optimized by factorial experiments and analysed for drug loading efficiency, gelation temperature and pH. Among these, composition G4 was selected and particle size, zeta potential and PDI were determined. The shelf life of the product at room temperature (25⁰C) and 60% RH was found to be 11.7 days, and halflife was 58.5 days, which is much greater than that of the pure drug in solution form. |
| 654 ## - SUBJECT ADDED ENTRY--FACETED TOPICAL TERMS | |
| Subject | <a href="Glioblastoma multiforme ">Glioblastoma multiforme </a> |
| -- | <a href="curcumin ">curcumin </a> |
| -- | <a href="nanoemulsion ">nanoemulsion </a> |
| -- | <a href="intranasal gel">intranasal gel</a> |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Srinivas Babu P |
| 773 0# - HOST ITEM ENTRY | |
| Host Biblionumber | 125265 |
| Host Itemnumber | 111176 |
| Place, publisher, and date of publication | Mumbai Indian Drugs Manufacturer's Association |
| Title | Indian Drugs |
| International Standard Serial Number | 0019-462X |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Koha item type | Journal Article |
| 773 0# - HOST ITEM ENTRY | |
| -- | JP489 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| -- | ddc |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Location (home branch) | Sublocation or collection (holding branch) | Date acquired | Koha issues (times borrowed) | Piece designation (barcode) | Koha date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | SNDT Juhu | SNDT Juhu | 20/01/2025 | JP489.3 | 20/01/2025 | 20/01/2025 | Journal Article |