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ASSESSMENT OF SUBCHRONIC ORAL TOXICITY AND SAFETY PROFILE OF SUVARNAPARPATI IN WISTAR RATS (Record no. 130764)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 01671nam a2200181 4500 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 250120b |||||||| |||| 00| 0 eng d |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Mahalaxmi M |
| 245 ## - TITLE STATEMENT | |
| Title | ASSESSMENT OF SUBCHRONIC ORAL TOXICITY AND SAFETY PROFILE OF SUVARNAPARPATI IN WISTAR RATS |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | P.62-71 |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. biblio.abstract | Suvarnaparpati is an ayurvedic metallic formulation used in gastronintestinal and respiratory disorders and as an antipyretic. The inclusion of heavy metals like mercury, sulfur and calcinated gold in suvarnaparpati raises concerns and may lead to safety issues. Consequently, this research explores the sub-chronic oral toxicity of suvarnaparpati in Wistar rats, adhering to OECD guideline 408, to analyse its safety profile. 24 Wistar rats were segmented into four groups. Animals received suvarnaparpati treatment continuously for 90 days at specified doses of 20.59 mg kg-1 (therapeutic dose-TD), 83.12 mg kg-1. (TD × 4) and 205.3 mg kg-1 (TD × 10). The effect of this formulation was examined on the water intake, food intake, urine analysis, haematology, serum biochemistry, organ-to-body weight ratio and histopathology of various organs, after 90 days of oral administration. Suvarnaparpati does not exhibit dose-related toxicity in Wistar rats of either sex across the said doses and may therefore be considered safe for human consumption. |
| 654 ## - SUBJECT ADDED ENTRY--FACETED TOPICAL TERMS | |
| Subject | <a href="Suvarnaparpati ">Suvarnaparpati </a> |
| -- | <a href="safety profile">safety profile</a> |
| -- | <a href="OECD">OECD</a> |
| -- | <a href="oral toxicity ">oral toxicity </a> |
| -- | <a href="rasashastra">rasashastra</a> |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Megha P. Aswale |
| 773 0# - HOST ITEM ENTRY | |
| Host Biblionumber | 125265 |
| Host Itemnumber | 111176 |
| Place, publisher, and date of publication | Mumbai Indian Drugs Manufacturer's Association |
| Title | Indian Drugs |
| International Standard Serial Number | 0019-462X |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Koha item type | Journal Article |
| 773 0# - HOST ITEM ENTRY | |
| -- | JP489 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| -- | ddc |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Location (home branch) | Sublocation or collection (holding branch) | Date acquired | Koha issues (times borrowed) | Piece designation (barcode) | Koha date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | SNDT Juhu | SNDT Juhu | 20/01/2025 | JP489.7 | 20/01/2025 | 20/01/2025 | Journal Article |