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Anti-inflammatory and anti-obesity activity of endophytic fungal isolates of Nardostachys jatamansi (Record no. 130815)
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| 000 -LEADER | |
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| fixed length control field | 02442nam a2200181 4500 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 250121b |||||||| |||| 00| 0 eng d |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Neha Kapoor |
| 245 ## - TITLE STATEMENT | |
| Title | Anti-inflammatory and anti-obesity activity of endophytic fungal isolates of Nardostachys jatamansi |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | p. 491-499 |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. biblio.abstract | The present study underpins the anti-obesity and anti-inflammatory activity of fungal endophytes inhabiting Nardostachys jatamansi of the high-altitude region of Uttarakhand. The study entails the recovery of 15 endophytic fungi from the leaves, inflorescence, and stem of N. Jatamansi, showing maximum colonisation in plant leaves. The anti-obesity and anti-inflammatory potential of the isolates was investigated via phenol red plate assay, L-asparaginase production, and albumin denaturation assay. The maximum albumin denaturation inhibitory activity of 74.8% was observed in -22JTM(I), followed by 70.3 and 67.6% in -6(b)JTM(L) and-7JTM(S), respectively. Three isolates were found to demonstrate potent L-asparaginase production, viz. -22JTM(I),-7JTM(S) and -25JTM(I). Interestingly, partial purification of the L-asparaginase demonstrated maximum enzyme production in -22JTM(I). In the phenol red plate assay, six isolates demonstrated anti-obesity activity, of which four isolates viz, -6(b)JTM (L), -7JTM (S), -23JTM (I) and -25JTM (I) exhibited 100% lipase inhibitory action. The free radical scavenging potential of the isolates as a contributor to the observed bioactivities was investigated. The isolates exhibited potent antioxidant activity with 70.9% by -23JTM (I) followed by -14JTM (L) and -22JTM (I) with 67.4 and 60.1%, respectively. The most potent isolate, -22JTM (I), was identified as Fusarium sp. by morpho-taxonomic tools. The present study showcases the promising therapeutic potential of fungal endophytes from N. jatamansi, demonstrating the repository of potent anti-obesity and anti-inflammatory chemistries. |
| 654 ## - SUBJECT ADDED ENTRY--FACETED TOPICAL TERMS | |
| Subject | <a href="Anti-inflammatory">Anti-inflammatory</a> |
| -- | <a href="Anti-obesity">Anti-obesity</a> |
| -- | <a href="Endophytic fungi">Endophytic fungi</a> |
| -- | <a href="Fusarium sp.">Fusarium sp.</a> |
| -- | <a href="Lipase inhibition">Lipase inhibition</a> |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Madeha Farooq |
| 773 0# - HOST ITEM ENTRY | |
| Host Biblionumber | 125285 |
| Host Itemnumber | 111204 |
| Place, publisher, and date of publication | New Delhi NISCAIR |
| Title | Indian Journal of Natural Products and Resources |
| International Standard Serial Number | 0976-0504 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Koha item type | Journal Article |
| 773 0# - HOST ITEM ENTRY | |
| -- | JP501 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| -- | ddc |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Location (home branch) | Sublocation or collection (holding branch) | Date acquired | Koha issues (times borrowed) | Piece designation (barcode) | Koha date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | SNDT Juhu | SNDT Juhu | 21/01/2025 | JP501.2 | 21/01/2025 | 21/01/2025 | Journal Article |