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Cytotoxicity and antioxidant activities of methanolic extract of Marchantia polymorpha and Dicranum scoparium using network pharmacology, molecular docking, and experimental approaches (Record no. 130817)
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| 000 -LEADER | |
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| fixed length control field | 02624nam a2200181 4500 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 250121b |||||||| |||| 00| 0 eng d |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Shivom Singh |
| 245 ## - TITLE STATEMENT | |
| Title | Cytotoxicity and antioxidant activities of methanolic extract of Marchantia polymorpha and Dicranum scoparium using network pharmacology, molecular docking, and experimental approaches |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | p. 500-514 |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. biblio.abstract | A comparative study was conducted to assess the antioxidant activity, cytotoxicity, and molecular docking of methanolic extracts from Marchantia polymorpha (Marchantiaceae) and Dicranum scoparium (Dicranaceae). The species M. polymorpha and D. scoparium remain largely unexplored in terms of their biochemical characterization and potential pharmacological activities. Phytoconstituents in the methanolic extracts were identified using spectral analysis. The cytotoxicity study utilized the MTT (3-(4, 5-dimethylthiazolyl-2)-2, 5-diphenyltetrazolium bromide) assay with U-87 human glial cell lines, while antioxidant activity was determined using the DPPH (2,2-diphenyl-1-picrylhydrazyl) assay. Additionally, a network pharmacology approach was employed to identify molecular targets in relation to cytotoxicity using the isolated compounds. Molecular docking was performed to evaluate the interactions between the isolated phytoconstituents of M. polymorpha and D. scoparium with the estrogen receptor ESR1 (Estrogen Receptor 1) (PDB ID: 1GWQ). The DPPH assay results demonstratedthat antioxidant activity increased with higher extract concentrations. The percentage scavenging activity ranged from 4.41 to88.05% for M. polymorpha and from 3.69 to 88.46% for D. scoparium, with minimum activity observed at 15.62 μg/mL andmaximum activity at 1000 μg/mL. The superoxide radical scavenging activity ranged from 0.00 to 48.09% for M. polymorphaand from 0.00 to 45.39% for D. scoparium. Network pharmacology analysis identified the estrogen receptor (ESR1) as acommon target involved in cancer. Molecular docking studies revealed that quercetin exhibited the strongest interactions withESR1 among all the selected phytoconstituents from M. polymorpha and D. scoparium |
| 654 ## - SUBJECT ADDED ENTRY--FACETED TOPICAL TERMS | |
| Subject | <a href="Anticancer">Anticancer</a> |
| -- | <a href="Bioinformatics">Bioinformatics</a> |
| -- | <a href="Estrogen receptor 1">Estrogen receptor 1</a> |
| -- | <a href="Mosses">Mosses</a> |
| -- | <a href="Scavenging ">Scavenging </a> |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Gaurav Bhadauriya |
| 773 0# - HOST ITEM ENTRY | |
| Host Biblionumber | 125285 |
| Host Itemnumber | 111204 |
| Place, publisher, and date of publication | New Delhi NISCAIR |
| Title | Indian Journal of Natural Products and Resources |
| International Standard Serial Number | 0976-0504 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Koha item type | Journal Article |
| 773 0# - HOST ITEM ENTRY | |
| -- | JP501 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| -- | ddc |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Location (home branch) | Sublocation or collection (holding branch) | Date acquired | Koha issues (times borrowed) | Piece designation (barcode) | Koha date last seen | Price effective from | Koha item type |
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| Dewey Decimal Classification | SNDT Juhu | SNDT Juhu | 21/01/2025 | JP501.3 | 21/01/2025 | 21/01/2025 | Journal Article |