SNDT WOMEN'S UNIVERSITY
BMK Knowledge Resource Centre
Vithaldas Vidyavihar, Juhu Tara Road,
Santacruz (West) Mumbai - 400049
PREPARATION AND CHARACTERIZATION OF MICROSPHERES UTILIZING RATE-CONTROLLING MEMBRANES FOR THE MANAGEMENT OF DIABETES MELLITUS (Record no. 131036)
[ view plain ]
| 000 -LEADER | |
|---|---|
| fixed length control field | 01779nam a2200133 4500 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 250211b |||||||| |||| 00| 0 eng d |
| 082 ## - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Item number | P.51-56 |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Nitu Patidar |
| 245 ## - TITLE STATEMENT | |
| Title | PREPARATION AND CHARACTERIZATION OF MICROSPHERES UTILIZING RATE-CONTROLLING MEMBRANES FOR THE MANAGEMENT OF DIABETES MELLITUS |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. biblio.abstract | The present research work aimed at the formulation of film-coated microspheres incorporating glibenclamide drug and their evaluation for the management of diabetes mellitus (DM). Microspheres were prepared by solvent evaporation methodology by the usage of ethyl cellulose as polymer, ethanol and dichloromethane as solvents and Tween 80® as a non-ionic surfactant. The film-coated membrane was prepared by pan coating method, incorporating ethyl cellulose, isopropyl alcohol, diethyl phthalate and sodium lauryl sulfate. This film membrane was coated on microspheres with the help of a spray gun. The efficiency of entrapment of the film coated microspheres of F5* batch, among different formulations, is highest and comes out to be in the range of 76.65±0.58. The percentage yield was observed to be 73.32±0.14. Morphological studies conducted by scanning electron microscope show spherical microspheres of uniform size. In vitro drug release study conducted of the coated microspheres of glibenclamide shows the highest amount of release of 97.44% in the F5*batch. The best-fit model was determined by the highest R2 value. Further, the developed formulation helps in reduction in dose dumping, with better patient compliance, and also masks the bitter taste of the drug. |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Nadeem A. Farooqui |
| 773 0# - HOST ITEM ENTRY | |
| Host Biblionumber | 125265 |
| Host Itemnumber | 109625 |
| Place, publisher, and date of publication | Mumbai Indian Drugs Manufacturer's Association |
| Title | Indian Drugs |
| International Standard Serial Number | 0019-462X |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Koha item type | Journal Article |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Koha normalized classification for sorting | Not for loan | Location (home branch) | Sublocation or collection (holding branch) | Date acquired | Koha issues (times borrowed) | Koha full call number | Piece designation (barcode) | Koha date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | P__5156 | SNDT Juhu | SNDT Juhu | 11/02/2025 | P.51-56 | JP68.5 | 11/02/2025 | 11/02/2025 | Journal Article |