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RP-HPLC METHOD DEVELOPMENT AND VALIDATION FOR QUANTITATIVE ESTIMATION OF TEMOZOLOMIDE AND (S) - PERILLYL ALCOHOL IN NANOPARTICULATE DOSAGE FORM (Record no. 131038)

MARC details
000 -LEADER
fixed length control field 02101nam a2200133 4500
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION
fixed length control field 250211b |||||||| |||| 00| 0 eng d
082 ## - DEWEY DECIMAL CLASSIFICATION NUMBER
Item number P.62-77
100 ## - MAIN ENTRY--PERSONAL NAME
Personal name Neha Desai
245 ## - TITLE STATEMENT
Title RP-HPLC METHOD DEVELOPMENT AND VALIDATION FOR QUANTITATIVE ESTIMATION OF TEMOZOLOMIDE AND (S) - PERILLYL ALCOHOL IN NANOPARTICULATE DOSAGE FORM
520 ## - SUMMARY, ETC.
Summary, etc. biblio.abstract A quick reverse-phase high-performance liquid chromatography (RP-HPLC) approach for the quantitative measurement of temozolomide (TMZ) and (s) - perillyl alcohol [(S)-POH] in a nanoparticulate system was developed and validated in the current work. The RP-HPLC method for the simultaneous estimation of TMZ and (S)-POH was developed using Agilent (Infinity 1260) HPLC system and ZorbaxC18 (4.6 x 150 mm i.d., 5µ; Agilent) as stationary phase. The optimized mobile phase comprised of ACN: water: MeOH (42:12:46 V/V/V; 42:08:50 V/V/V and 20:30:50 V/V/V) pumped at a flow rate of 0.8 mL min-1, 0.8 mL min-1 and 1 mL min-1, respectively. Drug separation was accomplished in an isocratic mode, and a PDA detector operating at 210 nm was used to track elution. The procedure was validated in accordance with ICH-Q2R1 standards. The responses of TMZ and (S)- POH were found to be linear at 50-175 μg mL-1 (ACN: water: MeOH 42:12:46 V/V/V and 42:08:50 V/V/V) and 50-175 μg mL-1 (ACN: water: MeOH 20:30:50 V/V/V) respectively. The percent recovery was determined to be between 97% and 103%, demonstrating that the method’s accuracy was adequate. The precision study’s percent relative standard deviation (% RSD) was less than 2, indicating the accuracy of the suggested procedure. It was discovered that the established method for the quantitative determination of TMZ and (S)- POH in bulk and in hollow gold nanoparticles was accurate, precise, and specific. The developed technique can be applied to TMZ and (S)- POH routine testing and quality control in bulk and nanoparticulate systems.
700 ## - ADDED ENTRY--PERSONAL NAME
Personal name Munira Momin
773 0# - HOST ITEM ENTRY
Host Biblionumber 125265
Host Itemnumber 109625
Place, publisher, and date of publication Mumbai Indian Drugs Manufacturer's Association
Title Indian Drugs
International Standard Serial Number 0019-462X
942 ## - ADDED ENTRY ELEMENTS (KOHA)
Koha item type Journal Article
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Withdrawn status Lost status Source of classification or shelving scheme Damaged status Koha normalized classification for sorting Not for loan Location (home branch) Sublocation or collection (holding branch) Date acquired Koha issues (times borrowed) Koha full call number Piece designation (barcode) Koha date last seen Price effective from Koha item type
    Dewey Decimal Classification   P__6277   SNDT Juhu SNDT Juhu 11/02/2025   P.62-77 JP68.7 11/02/2025 11/02/2025 Journal Article