SNDT WOMEN'S UNIVERSITY
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PHOSPHODIESTERASE INHIBITORS FOR TREATMENT OF ALZHEIMER'S DISEASE (Record no. 131122)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 01590nam a2200157 4500 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 250214b |||||||| |||| 00| 0 eng d |
| 082 ## - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Item number | P.7-22 |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Phool Chandra |
| 245 ## - TITLE STATEMENT | |
| Title | PHOSPHODIESTERASE INHIBITORS FOR TREATMENT OF ALZHEIMER'S DISEASE |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | P.7-22 |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. biblio.abstract | Cognitive decline with aging is a concern, particularly in neurodegenerative and mental diseases. Cognitive enhancers focus on cholinergic and monoaminergic systems, but Phosphodiesterases (PDEs) have gained interest in enhancing cognition by increasing intracellular accessibility of additional messengers. The present study sought to elucidate the effects of PDE-Inhibitors on perception, feasible underlying mechanisms, and their application to existing hypotheses regarding the formation of memories. The review examines literature from 2010-2023 on the effects of various PDE medications on mental processes, including studies on PDE-Is and their relation to blood flow, euphoria, and long-term potentiation. PDE inhibitors enhance brain information processing, concentration, memory, executive function and memory use, likely due to an LTP-interrelated mode of action. PDE2-Is and PDE9-Is are potential candidates for cognitive enhancement, but isoform-specific PDE-Is with minimal negative properties are needed to realize their potential fully. |
| 654 ## - SUBJECT ADDED ENTRY--FACETED TOPICAL TERMS | |
| Subject | <a href="PDE inhibitors">PDE inhibitors</a> |
| -- | <a href="sildenafil ">sildenafil </a> |
| -- | <a href="cognition ">cognition </a> |
| -- | <a href="cAMP">cAMP</a> |
| -- | <a href="cGMP">cGMP</a> |
| -- | <a href="memory ">memory </a> |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Himanshu Sharma |
| 773 0# - HOST ITEM ENTRY | |
| Host Biblionumber | 125265 |
| Host Itemnumber | 109909 |
| Place, publisher, and date of publication | Mumbai Indian Drugs Manufacturer's Association |
| Title | Indian Drugs |
| International Standard Serial Number | 0019-462X |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Koha item type | Journal Article |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Koha normalized classification for sorting | Not for loan | Location (home branch) | Sublocation or collection (holding branch) | Date acquired | Koha issues (times borrowed) | Koha full call number | Piece designation (barcode) | Koha date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | P__722 | SNDT Juhu | SNDT Juhu | 14/02/2025 | P.7-22 | JP288.1 | 14/02/2025 | 14/02/2025 | Journal Article |