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FABRICATION AND CHARACTERIZATION OF CENTRIFUGAL SPUN CIPROFLOXACIN-LOADED MICROFIBER DRESSING FOR THE TREATMENT OF DIABETIC FOOT ULCERS (Record no. 131125)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 01701nam a2200157 4500 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 250214b |||||||| |||| 00| 0 eng d |
| 082 ## - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Item number | 40-48 |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Mohd Fareed Shaikh |
| 245 ## - TITLE STATEMENT | |
| Title | FABRICATION AND CHARACTERIZATION OF CENTRIFUGAL SPUN CIPROFLOXACIN-LOADED MICROFIBER DRESSING FOR THE TREATMENT OF DIABETIC FOOT ULCERS |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | P.40-48 |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. biblio.abstract | Diabetic Foot Ulcers (DFUs) are open ulcers or sores on the foot with a bony prominence. They are a frequent manifestation of uncontrolled diabetes mellitus and often increase the risk of infection. DFUs typically take longer to heal, sometimes resulting in severe complications such as amputation. Our study aimed to develop a drug delivery system that could help to manage DFUs. We developed polymerbased fibers that were loaded with ciprofloxacin HCl via centrifugal spinning setup. The optimized polymeric fiber batch demonstrated over 90% drug entrapment, controlled drug release for 72 h, an average fiber diameter of 4.88 μm and porosity above 70%. The drug-loaded fibers showed antibacterial action against gram-negative (E. coli) and gram-positive (S. aureus) pathogens that are often prevalent in DFUs. Additionally, the fibers showed excellent hemocompatibility. Our study’s findings show great potential in managing DFUs, and future studies will explore the potential application of this drug delivery system in treating and managing diabetic foot ulcers. |
| 654 ## - SUBJECT ADDED ENTRY--FACETED TOPICAL TERMS | |
| Subject | <a href="Diabetic foot ulcer">Diabetic foot ulcer</a> |
| -- | <a href="diabetic foot infection">diabetic foot infection</a> |
| -- | <a href="microfiber centrifugal spinning ">microfiber centrifugal spinning </a> |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Payaam Vohra |
| 773 0# - HOST ITEM ENTRY | |
| Host Biblionumber | 125265 |
| Host Itemnumber | 109909 |
| Place, publisher, and date of publication | Mumbai Indian Drugs Manufacturer's Association |
| Title | Indian Drugs |
| International Standard Serial Number | 0019-462X |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Koha item type | Journal Article |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Koha normalized classification for sorting | Not for loan | Location (home branch) | Sublocation or collection (holding branch) | Date acquired | Koha issues (times borrowed) | Koha full call number | Piece designation (barcode) | Koha date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | P___4048 | SNDT Juhu | SNDT Juhu | 14/02/2025 | P. 40-48 | JP288.4 | 14/02/2025 | 14/02/2025 | Journal Article |