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DEVELOPMENT AND EVALUATION OF PHARMACEUTICALLY EQUIVALENT LEVOSALBUTAMOL DRY POWDER INHALER WITH INCREASED IN VITRO DEPOSITION (Record no. 131150)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02249nam a2200157 4500 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 250215b |||||||| |||| 00| 0 eng d |
| 082 ## - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Item number | P. 44-520 |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Suraj L. Dongare |
| 245 ## - TITLE STATEMENT | |
| Title | DEVELOPMENT AND EVALUATION OF PHARMACEUTICALLY EQUIVALENT LEVOSALBUTAMOL DRY POWDER INHALER WITH INCREASED IN VITRO DEPOSITION |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | P. 44-520 |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. biblio.abstract | The advancement and assessment of an efficient and safe dry powder inhaler formulation for levosalbutamol are critical for optimizing its therapeutic potential in managing chronic obstructive pulmonary disease (COPD). This study aims to provide an overview of the development process and evaluation outcomes of a levosalbutamol dry powder inhaler, including formulation development, physicochemical characterization and in vitro performance assessment. It employed a stepwise approach to develop and evaluate the inhaler. Initially, different excipients (Respitose®SV010, Respitose®ML006, Respitose®SV003, Lactohale LH100, Lactohale LH300) and particle size distributions were evaluated to optimize the formulation. Physicochemical characterization, such as particle size, shape and density were conducted using appropriate techniques. In vitro performance assessments, together with fine particle fractions, emitted dose and aerodynamic particle size distribution was determined using validated methods. The formulation development process resulted in an optimized levosalbutamol dry powder inhaler with desirable physicochemical properties, including uniform particle size distribution and suitable density for effective inhalation. In vitro assessments demonstrated favourable aerodynamic characteristics, with a high emitted dose and significant fine particle fraction, indicating efficient lung deposition and therapeutic efficacy. These findings support the potential of the levosalbutamol dry powder inhaler as an effective treatment option for respiratory conditions such as asthma and COPD. |
| 654 ## - SUBJECT ADDED ENTRY--FACETED TOPICAL TERMS | |
| Subject | <a href="Levosalbutamol">Levosalbutamol</a> |
| -- | <a href="dry powder inhaler ">dry powder inhaler </a> |
| -- | <a href="formulation development ">formulation development </a> |
| -- | <a href="physicochemical characterization ">physicochemical characterization </a> |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Minal R. Narkhede |
| 773 0# - HOST ITEM ENTRY | |
| Host Biblionumber | 125265 |
| Host Itemnumber | 109908 |
| Place, publisher, and date of publication | Mumbai Indian Drugs Manufacturer's Association |
| Title | Indian Drugs |
| International Standard Serial Number | 0019-462X |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Koha item type | Journal Article |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Koha normalized classification for sorting | Not for loan | Location (home branch) | Sublocation or collection (holding branch) | Date acquired | Koha issues (times borrowed) | Koha full call number | Piece designation (barcode) | Koha date last seen | Price effective from | Koha item type |
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| Dewey Decimal Classification | P___44520 | SNDT Juhu | SNDT Juhu | 15/02/2025 | P. 44-520 | JP287.4 | 15/02/2025 | 15/02/2025 | Journal Article |