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IN VIVO EVALUATION OF CURCUMIN REVEALs BIPHASIC ANGIOGENESis ACTIVITY IN ZEBRAFISH EXPERIMENTAL MODEL (Record no. 131154)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 01776nam a2200157 4500 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 250217b |||||||| |||| 00| 0 eng d |
| 082 ## - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Item number | P. 63-69 |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Priyanka P. Nigade |
| 245 ## - TITLE STATEMENT | |
| Title | IN VIVO EVALUATION OF CURCUMIN REVEALs BIPHASIC ANGIOGENESis ACTIVITY IN ZEBRAFISH EXPERIMENTAL MODEL |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | P. 63-69 |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. biblio.abstract | Curcumin, a prominent polyphenol compound present in Curcumin longa L., exhibits diverse pharmacological and biological effects. Its hydrophobic nature and poor bioavailability necessitate its solubilization in an amphiphilic solvent such as dimethyl sulfoxide (DMSO) for research purpose. The present study aims to characterize a DMSO-solubilized curcumin and assess the angiogenesis potential of curcumin in zebrafish and chick chorioallantoic membrane (CAM) assay. Curcumin was characterized using UV-Vis spectrophotometry and the angiogenesis effect was evaluated using CAM and zebrafish embryos. The DMSO-solubilized curcumin’s UV-Vis spectrum revealed hypsochromatic shift in wavelength maximum from 425 to 347 nm, indicating solvent-curcumin interaction. Evaluation of angiogenesis activity in the CAM and zebrafish demonstrated dose-dependent promotion of angiogenesis. Curcumin’s biphasic, dose-dependent angiogenesis feature was validated in CAM and zebrafish models, affirming utility of zebrafish model for angiogenesis efficacy study. The solvent-curcumin interactions, molecular properties, and their therapeutic consequences need further investigation. |
| 654 ## - SUBJECT ADDED ENTRY--FACETED TOPICAL TERMS | |
| Subject | <a href="Curcumin ">Curcumin </a> |
| -- | <a href="biphasic activities ">biphasic activities </a> |
| -- | <a href="zebrafish ">zebrafish </a> |
| -- | <a href="angiogenesis ">angiogenesis </a> |
| -- | <a href="hypsochromatic effect ">hypsochromatic effect </a> |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ketaki V. Gurav |
| 773 0# - HOST ITEM ENTRY | |
| Host Biblionumber | 125265 |
| Host Itemnumber | 109908 |
| Place, publisher, and date of publication | Mumbai Indian Drugs Manufacturer's Association |
| Title | Indian Drugs |
| International Standard Serial Number | 0019-462X |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Koha item type | Journal Article |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Koha normalized classification for sorting | Not for loan | Location (home branch) | Sublocation or collection (holding branch) | Date acquired | Koha issues (times borrowed) | Koha full call number | Piece designation (barcode) | Koha date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | P___6369 | SNDT Juhu | SNDT Juhu | 17/02/2025 | P. 63-69 | JP287.6 | 17/02/2025 | 17/02/2025 | Journal Article |