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DESIGN AND OPTIMIZATION OF OCULAR INSERTS FOR PROLONGED DELIVERY OF CIPROFLOXACIN WITH CORTICOSTEROID (Record no. 131167)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 01828nam a2200157 4500 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 250218b |||||||| |||| 00| 0 eng d |
| 082 ## - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Item number | P.30-37 |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Swati M. Keny |
| 245 ## - TITLE STATEMENT | |
| Title | DESIGN AND OPTIMIZATION OF OCULAR INSERTS FOR PROLONGED DELIVERY OF CIPROFLOXACIN WITH CORTICOSTEROID |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | P.30-37 |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. biblio.abstract | Ocular drug delivery is very challenging and fascinating for pharmaceutical researchers, especially in the treatment of ocular conjunctivitis. The challenges include delivery of the drug to the eye without causing permanent tissue damage while maintaining a stable therapeutic level at the site of action for a prolonged period of time. The present work focuses on the treatment of ocular conjunctivitis by using combined mechanisms of fluroquinolone antibiotics, providing sustained release of drug from ocular inserts, and using corticosteroid for anti-inflammatory effect and providing comfort to the patient. Quinolone antibiotics, anti-inflammatory agents and polymers with excipients were procured from pharmaceutical companies as gift samples. Different combinations of antibiotics and anti-inflammatory agents were prepared by solvent cast method and the dried films were cut into defined size containing drug and evaluated for different parameters and sustained drug release. Based on in vitro, in vivo correlation stability studies, the formulation (antibiotic + anti-inflammatory agent) promising the best once a day sustained release of the drug has been chosen. |
| 654 ## - SUBJECT ADDED ENTRY--FACETED TOPICAL TERMS | |
| Subject | <a href="Quinolone antibiotics ">Quinolone antibiotics </a> |
| -- | <a href="anti-inflammatory agents ">anti-inflammatory agents </a> |
| -- | <a href="conjunctivitis ">conjunctivitis </a> |
| -- | <a href="occuserts ">occuserts </a> |
| -- | <a href="in vitro release pattern ">in vitro release pattern </a> |
| -- | <a href="physico-chemical evaluation ">physico-chemical evaluation </a> |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Leena A. Sawaikar |
| 773 0# - HOST ITEM ENTRY | |
| Host Biblionumber | 125265 |
| Host Itemnumber | 109669 |
| Place, publisher, and date of publication | Mumbai Indian Drugs Manufacturer's Association |
| Title | Indian Drugs |
| International Standard Serial Number | 0019-462X |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Koha item type | Journal Article |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Koha normalized classification for sorting | Not for loan | Location (home branch) | Sublocation or collection (holding branch) | Date acquired | Koha issues (times borrowed) | Koha full call number | Piece designation (barcode) | Koha date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | P__3037 | SNDT Juhu | SNDT Juhu | 18/02/2025 | P.30-37 | JP113.3 | 18/02/2025 | 18/02/2025 | Journal Article |