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Investigation on the Phytochemistry, Antioxidant, and Hepatoprotective Properties of the Ethanolic Extract of Gymnostachyum febrifugum Benth (Record no. 131228)
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| fixed length control field | 02084nam a22001337a 4500 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 250228b |||||||| |||| 00| 0 eng d |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Lekha Mathew |
| 245 ## - TITLE STATEMENT | |
| Title | Investigation on the Phytochemistry, Antioxidant, and Hepatoprotective Properties of the Ethanolic Extract of Gymnostachyum febrifugum Benth |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | pg.496-502 |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. biblio.abstract | Background: The phytochemical evaluation of the ethanolic extract of the plant, Gymnostachyum febrifugum Benth. (Acanthaceae family) was carried out to evaluate its therapeutic potential. Despite being part of traditional medicine, not much research has been done on the plant. Materials and Methods: The study aimed to understand the plant’s phytochemistry and evaluate its therapeutic potential. For this purpose, DPPH, ABTS, FRAP, Total Antioxidant Assay, MTT Assay, and HR-LCMS techniques were employed. Results: Major secondary metabolites in the ethanolic extract were flavonoids, tannins, phenolics, and steroids. The free radical scavenging capacity of the ethanolic extract of the plant was evaluated using four different methods, proving the plant to possess high antioxidant properties. Hence, the hepatoprotective potential of ethanolic extract was evaluated using an MTT assay on Hep G2 cells induced with hepatotoxicity using Acetaminophen. When treated with ethanolic extract, the cell viability was found to be 85.32% at 12.5 μg/mL concentration. IC50 for ethanolic extract was attained at 75.77 μg/mL. Also, chemical characterization of the extract was performed using the HR-LCMS technique. Around 64 compounds were obtained in chromatogram using positive ESI mode, of which 24 are unknown and 40 are known compounds. Out of 37 compounds obtained in the negative ESI mode, 27 were known, and 10 were unknown. |
| 654 ## - SUBJECT ADDED ENTRY--FACETED TOPICAL TERMS | |
| Subject | <a href=" Gymnostachyum febrifugum Benth. ,"> Gymnostachyum febrifugum Benth. ,</a> |
| -- | <a href=", Acanthaceae, ">, Acanthaceae, </a> |
| -- | <a href=", Antioxidant assay,">, Antioxidant assay,</a> |
| -- | <a href=" HR-LC MS, "> HR-LC MS, </a> |
| -- | <a href=" MTT assay, "> MTT assay, </a> |
| -- | <a href="hepatoprotective.">hepatoprotective.</a> |
| 773 0# - HOST ITEM ENTRY | |
| Host Biblionumber | 125266 |
| Host Itemnumber | 109790 |
| Place, publisher, and date of publication | Banglore Association of Pharmaceutical Tearchers of India |
| Title | Indian Journal of Pharmaceutical Education and Research |
| International Standard Serial Number | 0019-5464 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Koha item type | Journal Article |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Location (home branch) | Sublocation or collection (holding branch) | Date acquired | Koha issues (times borrowed) | Piece designation (barcode) | Koha date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | SNDT Juhu | SNDT Juhu | 28/02/2025 | jp225.17 | 28/02/2025 | 28/02/2025 | Journal Article |