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Boswellic Acid Loaded Nanoemulgel for Rheumatoid Arthritis: Formulation Design and Optimization by QbD, in vitro, ex vivo, and in vivo Evaluation (Record no. 131240)
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| fixed length control field | 02142nam a2200133 4500 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 250228b |||||||| |||| 00| 0 eng d |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Yogesh Mahadeo Amgaonkar |
| 245 ## - TITLE STATEMENT | |
| Title | Boswellic Acid Loaded Nanoemulgel for Rheumatoid Arthritis: Formulation Design and Optimization by QbD, in vitro, ex vivo, and in vivo Evaluation |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | pg.546-554 |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. biblio.abstract | Background: Topical delivery of medication is often considered to be the best choice due to benefits such as avoidance of gastric degradation, first pass metabolism along with effortless application and retrieval. In topical delivery, the types of the vehicles and the physicochemical characteristics of drug are the prime variables that control the drug release and the therapeutic efficacy. The main component of Boswellia, Boswellic Acid (BA), is assumed to be accountable for the majority of pharmacologic effects. Nanoemulgel combines the benefits of nano-emulsions and the gels. Materials and Methods: The present work carried out with an objective of formulation of topical nanoemulgel of boswellic acid containing carbopol 934 and liquid paraffin as oil base. Results: The prepared nanoemulgel characterized for the various parameters such as, in vitro, ex vivo permeation and in vivo anti-inflammatory activity. The optimized nanoemulsion consisted of carbopol 934 and surfactant mix ratio (tween 80:Span20::1:1), in 1, 1.5 and 2 % w/w. The in vitro, ex vivo permeation of BA from nanoemulgel were found to be 90±0.33% and 85.5±1.2% at 12 hr respectively. Conclusion: Topical application of BA nanoemulgel formulation significantly reduced the inflammation by reducing the serum IL-6 concentration compared with the arthritic rats. The research findings showed that BA nanoemulgel has the ability to increase penetration through the skin and produce an anti-inflammatory impact. |
| 654 ## - SUBJECT ADDED ENTRY--FACETED TOPICAL TERMS | |
| Subject | <a href="Boswellic acid">Boswellic acid</a> |
| -- | <a href="Nanoemulgel, ">Nanoemulgel, </a> |
| -- | <a href=", Anti-inflammatory effect, ">, Anti-inflammatory effect, </a> |
| -- | <a href="Rheumatoid arthritis,">Rheumatoid arthritis,</a> |
| -- | <a href="Topical delivery.">Topical delivery.</a> |
| 773 0# - HOST ITEM ENTRY | |
| Host Biblionumber | 125266 |
| Host Itemnumber | 109790 |
| Place, publisher, and date of publication | Banglore Association of Pharmaceutical Tearchers of India |
| Title | Indian Journal of Pharmaceutical Education and Research |
| International Standard Serial Number | 0019-5464 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Koha item type | Journal Article |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Location (home branch) | Sublocation or collection (holding branch) | Date acquired | Koha issues (times borrowed) | Piece designation (barcode) | Koha date last seen | Price effective from | Koha item type |
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| Dewey Decimal Classification | SNDT Juhu | SNDT Juhu | 28/02/2025 | jp225.23 | 28/02/2025 | 28/02/2025 | Journal Article |