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Ameliorative Effect of Cichoric Acid against Diabetes Associated Cognitive Decline with Emphasis on Neurobehavioral Activity, Aβ and AChE (Record no. 131248)
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| 000 -LEADER | |
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| fixed length control field | 02400nam a22001337a 4500 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 250228b |||||||| |||| 00| 0 eng d |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Sunil Shukla |
| 245 ## - TITLE STATEMENT | |
| Title | Ameliorative Effect of Cichoric Acid against Diabetes Associated Cognitive Decline with Emphasis on Neurobehavioral Activity, Aβ and AChE |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | p595-602 |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. biblio.abstract | Background: Diabetes Mellitus (DM) is closely related to degenerative and functional abnormalities of the CNS. Studies indicate that an alteration in the CNS brought on by persistent hyperglycemia is primarily responsible for diabetes-related cognitive impairment proving a clear connection between DM and cognitive impairment. Anti-oxidants, antihyperglycemics, and insulin-sensitizing substances can lessen this diabetes-related cognitive impairment. Due to the anti-diabetic and antioxidant characteristics, Cichoric Acid (CA) might have an impact on the cognitive impairment brought on by diabetes. Aim: The goal of the current investigation was to determine if CA protects against cognitive deterioration in Streptozotocin (STZ)-induced diabetic rats. Materials and Methods: Diabetes was induced by a single i.p. injection of Streptozotocin (STZ) 60 mg per kg of body weight. After development of persistent hyperglycemia rats were treated with Cichoric Acid for both acute (14 days) and chronic (28 days) conditions followed by behavioural and biochemical analysis. Results: The levels of Aβ(1-42), serum glucose, AChE activity, and MDA levels were markedly reduced after CA treatment in comparison to the STZ infused group. In contrast, the levels of GSH were significantly elevated by CA therapy. CA therapy improved learning and memory ability in both acquisition and probe trials (Morri’s water maze tests), outperforming the STZ injection group. However, CA was found to mitigate the effects of STZ more significantly at the chronic level of treatment compared to the acute one. Conclusion: findings revealed that CA reduced cognitive impairment brought on by STZ, suggesting that CA has a lot of potential combat cognitive impairment. |
| 654 ## - SUBJECT ADDED ENTRY--FACETED TOPICAL TERMS | |
| Subject | <a href="Diabetes mellitus, ">Diabetes mellitus, </a> |
| -- | <a href="Cognitive dysfunction, ">Cognitive dysfunction, </a> |
| -- | <a href="Cichoric acid, ">Cichoric acid, </a> |
| -- | <a href="Oxidative stress, ">Oxidative stress, </a> |
| -- | <a href="Beta amyloid, ">Beta amyloid, </a> |
| -- | <a href="Acetylcholinesterase.">Acetylcholinesterase.</a> |
| 773 0# - HOST ITEM ENTRY | |
| Host Biblionumber | 125266 |
| Host Itemnumber | 109790 |
| Place, publisher, and date of publication | Banglore Association of Pharmaceutical Tearchers of India |
| Title | Indian Journal of Pharmaceutical Education and Research |
| International Standard Serial Number | 0019-5464 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Koha item type | Journal Article |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Location (home branch) | Sublocation or collection (holding branch) | Date acquired | Koha issues (times borrowed) | Piece designation (barcode) | Koha date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | SNDT Juhu | SNDT Juhu | 28/02/2025 | JP225.27 | 28/02/2025 | 28/02/2025 | Journal Article | |||||
| Dewey Decimal Classification | SNDT Juhu | SNDT Juhu | 28/02/2025 | JP225.28 | 28/02/2025 | 28/02/2025 | Journal Article |