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Synergic action of plant derivatives and honey for high efficacy of Dawa-ul kurkum formulation against hepatocellular carcinoma (Record no. 131333)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02428nam a2200145 4500 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 250310b |||||||| |||| 00| 0 eng d |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Seyedeh Sara Kamyab |
| 245 ## - TITLE STATEMENT | |
| Title | Synergic action of plant derivatives and honey for high efficacy of Dawa-ul kurkum formulation against hepatocellular carcinoma |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | P.1044-1054 |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. biblio.abstract | Hepatocellular carcinoma with high incidence and poor survival stands as a major global health burden. Various challenges involved in drug therapies impede their efficacy for substantial protective effects. They emphasize the necessity for the development of safe and affordable options suitable for long-term treatment. The present study has explored the therapeutic potential of traditional Dawa-ul-kurkum formulation for anticancer effects against hepatocellular carcinoma (HCC). The formulation and its individual ingredients were screened for cytotoxic effects, induction of apoptosis, and cell cycle arrest on HepG2 cell line. Dawa-ul-kurkum was further evaluated for regression of tumor growth in diethylnitrosamine (DEN) induced HCC rat models. Low, medium, and high doses of the formulation were fed orally to the test groups. A Combination of Dawa-ul-kurkum with the anticancer drug Doxorubicin was tested for assessment of adjuvant therapy. The classical dosage form with honey of each ingredient plant drug displayed enhanced cytotoxic effect and pharmacologically significant IC50 values. The Dawa-ul- kurkum formulation was superior in inducing apoptosis and arresting cells in the G0-G1 phase of the cell cycle. Significant regression of tumor growth and reversal of biochemical parameters in DEN-induced HCC rat study endorsed its prominent anticancer effect. The promising potential to induce apoptosis, cell cycle arrest, and regression in tumor growth validated the traditional Dawa-ul-kurkum formulation for anti-hepatoma activity. The study convincingly promotes the use of Dawa-ul-kurkum formulation for the development of a cost-effective and safe therapeutic strategy against HCC. |
| 654 ## - SUBJECT ADDED ENTRY--FACETED TOPICAL TERMS | |
| Subject | <a href="Anticancer,">Anticancer,</a> |
| -- | <a href="Cost-effective,">Cost-effective,</a> |
| -- | <a href="Hepatocellular carcinoma">Hepatocellular carcinoma</a> |
| -- | <a href="Honey">Honey</a> |
| -- | <a href="Unani medicine">Unani medicine</a> |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Alpana Moghe |
| 773 0# - HOST ITEM ENTRY | |
| Host Biblionumber | 125286 |
| Host Itemnumber | 111151 |
| Place, publisher, and date of publication | New Delhi NISCAIR |
| Title | Indian Journal of Traditional Knowledge |
| International Standard Serial Number | 0972-5938 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Koha item type | Journal Article |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Location (home branch) | Sublocation or collection (holding branch) | Date acquired | Koha issues (times borrowed) | Piece designation (barcode) | Koha date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | SNDT Juhu | SNDT Juhu | 10/03/2025 | JP.472.4 | 10/03/2025 | 10/03/2025 | Journal Article |