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Reversal of restraint stress caused dendritic atropy in rats by Nardostachys jatamansi (Record no. 131420)
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| fixed length control field | 02433nam a2200133 4500 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 250319b |||||||| |||| 00| 0 eng d |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Gloria Karkada |
| 245 ## - TITLE STATEMENT | |
| Title | Reversal of restraint stress caused dendritic atropy in rats by Nardostachys jatamansi |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | p353-361 |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. biblio.abstract | Hippocampus and prefrontal cortex of brain have distinct role in encoding and retrieval of memories. Uncontrollable stress may influence the structural alterations of limbic brain regions and atropy of neurons mainly in the regions like the prefrontal cortex and hippocampus. Nardostachys jatamansi (D. Don) DC (NJE) is a perennial herb and is known for its anti-Parkinson’s, hepatoprotective, neuroprotective, hypotensive and anti-diabetic activities. Even though, it is an effective therapeutic intervention for memory impairment but, its effect on the neurons of the hippocampus is not clear. In this context, the effect of NJE on chronic restraint stress induced dendritic atropy in rats was studied. Male Wistar rats underwent 21 days of restraint stress in a close fitting rodent restrainer. In combined treatment groups rats were treated with alcoholic extract of NJE at dosage of 200 mg/kg bw for 21 days along with chronic restraint stress. The dendritic morphology of neurons was studied in Golgi-impregnated sections. Stress produced dendritic atropy significantly increased the dendritic branching and intersections in experimental rats. Interestingly, treatment of stressed rats with NJE extract resulted in the reversal of stress induced the dendritic atrophy. These results demonstrate that atrophy of dendritic neurons caused by chronic restraint stress may be responsible for learning and memory impairment. Co-treatment of rats with NJE showed enhancement in the dendritic branching in the hippocampus. Furthermore, NJE treatment significantly increased superoxide dismutase activity and total antioxidant capacity in frontal cortex, hippocampus and striatum regions of brain. Thus, our findings suggest that NJE is a potential neuroprotector, which might be beneficial in the treatment of stress induced memory impairment |
| 654 ## - SUBJECT ADDED ENTRY--FACETED TOPICAL TERMS | |
| Subject | <a href="Dendritic atropy">Dendritic atropy</a> |
| -- | <a href="Hippocampus">Hippocampus</a> |
| -- | <a href="Nardostachys jatamansi">Nardostachys jatamansi</a> |
| -- | <a href="Neuron">Neuron</a> |
| -- | <a href="Stress">Stress</a> |
| -- | <a href="Wistar rats ">Wistar rats </a> |
| 773 0# - HOST ITEM ENTRY | |
| Host Biblionumber | 131419 |
| Host Itemnumber | 112188 |
| Main entry heading | Shehanaz Alam |
| Title | Traditional knowledge of agriculture in Bengali folk songs |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Koha item type | Journal Article |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Location (home branch) | Sublocation or collection (holding branch) | Date acquired | Koha issues (times borrowed) | Piece designation (barcode) | Koha date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | SNDT Juhu | SNDT Juhu | 19/03/2025 | JP179.7 | 19/03/2025 | 19/03/2025 | Journal Article |