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Evaluation of in vitro immunomodulatory and antimicrobial activity with safety study of granules of Naque Nazla (Record no. 131451)
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| 000 -LEADER | |
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| fixed length control field | 01974nam a2200145 4500 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 250320b |||||||| |||| 00| 0 eng d |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Khan Nusrat Bano Nafees Ahmada |
| 245 ## - TITLE STATEMENT | |
| Title | Evaluation of in vitro immunomodulatory and antimicrobial activity with safety study of granules of Naque Nazla |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | p.409-419 |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. biblio.abstract | Common cold and flu are frequently occurring in humans, if not managed, can cause secondary infections and other complications. It may be minimized by boosting immunity, which can be done by Unani Medicine. Objective of this study is to evaluate in vitro immunomodulatory and antimicrobial activity and safety of granules of Naque Nazla, a famous Unani infusion / decoction. Naque Nazla granules (NNG) were tested for its immunomodulatory activity by lymphocyte proliferation assay and macrophage phagocytosis and antimicrobial activity by well diffusion method. LC-MS and GC-MS was done for standardization. Acute toxicity study was carried as per OECD guidelines 423, to evaluate safety of granules. THP-1 cells study displayed EC50 value of 997.6 μg/mL with a proliferation of 53.95% at 1280 μg/mL. Phagocytosis assay displayed 67.85% phagocytosis at 1280 μg/mL, antimicrobial activity was tested against common respiratory tract bacteria which showed susceptibility against Klebsiella pneumoniae, Salmonella spp., Staphylococcus aureus, and Streptococcus pyogenes. LC-MS and GC-MS fingerprinting data was set in and revealed the presence of many phytochemicals. Acute toxicity study displayed the drug safe up to 2000 mg/kg. NNG displayed immunomodulatory and antimicrobial activity in in vitro study and was also found safe. |
| 654 ## - SUBJECT ADDED ENTRY--FACETED TOPICAL TERMS | |
| Subject | <a href="Antimicrobial activity">Antimicrobial activity</a> |
| -- | <a href="Granule">Granule</a> |
| -- | <a href="Immunomodulation">Immunomodulation</a> |
| -- | <a href="Naque Nazla">Naque Nazla</a> |
| -- | <a href="Unani medicine ">Unani medicine </a> |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Abdul Waduda, |
| 773 0# - HOST ITEM ENTRY | |
| Host Biblionumber | 125286 |
| Host Itemnumber | 109709 |
| Place, publisher, and date of publication | New Delhi NISCAIR |
| Title | Indian Journal of Traditional Knowledge |
| International Standard Serial Number | 0972-5938 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Koha item type | Journal Article |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Location (home branch) | Sublocation or collection (holding branch) | Date acquired | Koha issues (times borrowed) | Piece designation (barcode) | Koha date last seen | Price effective from | Koha item type |
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| Dewey Decimal Classification | SNDT Juhu | SNDT Juhu | 20/03/2025 | JP152.5 | 20/03/2025 | 20/03/2025 | Journal Article |