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A SCAFFOLD OF CENTRAL COMPOSITE DESIGN (CCD) IN QUALITY BY DESIGN (QBD) FABRICATION AND ASSESSMENT OF MUCOADHESIVE AMOXICILLIN MICROSPHERES (Record no. 131679)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 01574nam a2200145 4500 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 250513b |||||||| |||| 00| 0 eng d |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Prarthna Lakhera |
| 245 ## - TITLE STATEMENT | |
| Title | A SCAFFOLD OF CENTRAL COMPOSITE DESIGN (CCD) IN QUALITY BY DESIGN (QBD) FABRICATION AND ASSESSMENT OF MUCOADHESIVE AMOXICILLIN MICROSPHERES |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | p20-27 |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. biblio.abstract | <br/>In the present investigation, amoxicillin loaded mucoadhesive microspheres were prepared and characterized. The prepared formulation was optimized using two factorial three level central composite experimental design employing response surface methodology. Drug loading (%), and concentration of HPMC (%) were chosen as independent variables. The response yield and drug release were designated as dependable variable. The characterization of fabricated microspheres was conducted by FTIR, scanning electron microscopy (SEM), entrapment efficiency and particle size analysis. Wash out tests and mucoadhesive test of prepared formulations were also carried out. SEM studies revealed the surface smoothness of fabricated microspheres. Further, in vitro release study of preparations was conducted and the results were best fitted into Higuchi kinetic model. The percentage yield and drug release from optimized batch was found to be 72.08 and 85.53, respectively. |
| 654 ## - SUBJECT ADDED ENTRY--FACETED TOPICAL TERMS | |
| Subject | <a href="Amoxicillin trihydrate">Amoxicillin trihydrate</a> |
| -- | <a href="evaluation ">evaluation </a> |
| -- | <a href="microspheres">microspheres</a> |
| -- | <a href="responses surface methodology">responses surface methodology</a> |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Minkal Tuteja |
| 773 0# - HOST ITEM ENTRY | |
| Host Biblionumber | 125265 |
| Host Itemnumber | 112354 |
| Place, publisher, and date of publication | Mumbai Indian Drugs Manufacturer's Association |
| Title | Indian Drugs |
| International Standard Serial Number | 0019-462X |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Koha item type | Journal Article |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Location (home branch) | Sublocation or collection (holding branch) | Date acquired | Koha issues (times borrowed) | Piece designation (barcode) | Koha date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | SNDT Juhu | SNDT Juhu | 13/05/2025 | JP601.2 | 13/05/2025 | 13/05/2025 | Journal Article |