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Epigenetic DNA methylation markers: a non-invasive diagnostic approach for urinary bladder cancer (Record no. 131777)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 01649nam a2200133 4500 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 250624b |||||||| |||| 00| 0 eng d |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Amandeep Singh |
| 245 ## - TITLE STATEMENT | |
| Title | Epigenetic DNA methylation markers: a non-invasive diagnostic approach for urinary bladder cancer |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | P 398-403 |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. biblio.abstract | Urinary bladder cancer (UBC) has high recurrence<br/>rates, making early detection vital. Promoter DNA<br/>methylation of CALCA, CCNA1 and P16 genes can<br/>serve as non-invasive biomarkers. The objective of the<br/>present study is to evaluate the promoter methylation<br/>status of CCNA1, CALCA and P16 genes in the blood of<br/>UBC patients compared to controls, and to explore<br/>their utility as non-invasive biomarkers. Blood samples<br/>from 169 participants, including 89 UBC patients and<br/>80 controls, were analysed. Blood samples were collected, DNA was extracted for bisulphite conversion,<br/>followed by methylation-specific polymerase chain<br/>reaction (PCR). Statistical analyses determined the<br/>association between methylation status and clinical<br/>features. Methylation was detected in CCNA1 (66.2%),<br/>CALCA (53.9%), and P16 (72%) in UBC patients, significantly higher than in controls. Combined analysis<br/>of these three genes provided a sensitivity of 85% and<br/>specificity of 80% for UBC detection. Blood-based<br/>methylation of CCNA1, CALCA and P16 genes emerged<br/>as a promising non-invasive biomarker for early UBC<br/>detection. Further validation in larger cohorts is required. |
| 654 ## - SUBJECT ADDED ENTRY--FACETED TOPICAL TERMS | |
| Subject | <a href="DNA methylation">DNA methylation</a> |
| -- | <a href="methylation-specific PCR">methylation-specific PCR</a> |
| -- | <a href="non-invasive biomarkers">non-invasive biomarkers</a> |
| -- | <a href="urinary bladder cancer">urinary bladder cancer</a> |
| 773 0# - HOST ITEM ENTRY | |
| Host Biblionumber | 125299 |
| Host Itemnumber | 112521 |
| Title | Current Science |
| International Standard Serial Number | 0011-3891 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Koha item type | Journal Article |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Location (home branch) | Sublocation or collection (holding branch) | Date acquired | Koha issues (times borrowed) | Piece designation (barcode) | Koha date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | SNDT Juhu | SNDT Juhu | 24/06/2025 | JP669.5 | 24/06/2025 | 24/06/2025 | Journal Article |