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Evaluation of pharmacological properties and identification of biopotent compounds of the medicinal herb Justicia simplex D. Don (Record no. 131857)
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| 000 -LEADER | |
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| fixed length control field | 02405nam a2200145 4500 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 250624b |||||||| |||| 00| 0 eng d |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Saira Salim |
| 245 ## - TITLE STATEMENT | |
| Title | Evaluation of pharmacological properties and identification of biopotent compounds of the medicinal herb Justicia simplex D. Don |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | PP310-318 |
| 500 ## - GENERAL NOTE | |
| General note | Innovative research is going on in search of novel, safer, and more effective drugs that are affordable to the common man. The present study evaluates the wound healing, antibacterial, antifungal and anticancer efficacies of leaves of the folk medicinal herb Justicia simplex, identifies the bioactive compounds present in the extract and predicts the drug likeness and pharmacological activities of the compounds. The wound healing efficacy of the extract was evaluated by in vitro scratch assay, antimicrobial activities by agar well diffusion method, antioxidant activity by DPPH radical scavenging assay, cytotoxic activity by MTT assay, morphological studies were conducted using phase contrast microscopy, and cell apoptosis by acridine orange and ethidium bromide double staining method. FTIR and HRMS analyses were employed to identify the bioactive compounds present in the extract. Physicochemical characters and drug-likeness of the compounds were predicted employing the SWISSADME web tool and pharmacological activities by the PASS online software.The study proved the effectiveness of J. simplex against pathogenic bacteria, fungi, and its wound healing, anticancer and cell apoptotic properties. The bioactive compounds identified were ethyl 6,9,12-hexadecatrienoate, 17-octadecynoic acid, n-hexadecanoic acid and ethylene glycol 0,0-di(pivaloyl). Pa > 0.7 indicates that all the compounds are very likely to exhibit anti-eczematic activity and three compounds obey the Lipinski rule of drug likeness. While the study highlights J. simplex as a promising candidate for novel drug discovery, further research is needed to fully explore and validate its therapeutic potential. |
| 654 ## - SUBJECT ADDED ENTRY--FACETED TOPICAL TERMS | |
| Subject | <a href="Anticancer">Anticancer</a> |
| -- | <a href="Antimicrobial">Antimicrobial</a> |
| -- | <a href="FTIR">FTIR</a> |
| -- | <a href="HRMS">HRMS</a> |
| -- | <a href=" Justicia simplex"> Justicia simplex</a> |
| -- | <a href=" MTT assay"> MTT assay</a> |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Gopika Jayasenan |
| -- | Pradeep Kumar R |
| 773 0# - HOST ITEM ENTRY | |
| Host Biblionumber | 131856 |
| Host Itemnumber | 112773 |
| Main entry heading | B Usha Devi |
| Title | Evaluating the efficacy of yogic practices and mud therapy in influencing biochemical parameters among middle aged women with type 2 diabetes mellitus – A randomized controlled trial study |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Koha item type | Journal Article |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Location (home branch) | Sublocation or collection (holding branch) | Date acquired | Koha issues (times borrowed) | Piece designation (barcode) | Koha date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | SNDT Juhu | SNDT Juhu | 24/06/2025 | jp718.2 | 24/06/2025 | 24/06/2025 | Journal Article |