SNDT WOMEN'S UNIVERSITY
BMK Knowledge Resource Centre
Vithaldas Vidyavihar, Juhu Tara Road,
Santacruz (West) Mumbai - 400049
FORMULATION AND CHARACTERIZATION OF PH-INDUCED IONIC GELATION CIMETIDINE ORAL IN SITU GEL FOR TARGETED GASTRIC DELIVERY (Record no. 131890)
[ view plain ]
| 000 -LEADER | |
|---|---|
| fixed length control field | 01573nam a2200145 4500 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 250704b |||||||| |||| 00| 0 eng d |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Chetan Kumar Shettya |
| 245 ## - TITLE STATEMENT | |
| Title | FORMULATION AND CHARACTERIZATION OF PH-INDUCED IONIC GELATION CIMETIDINE ORAL IN SITU GEL FOR TARGETED GASTRIC DELIVERY |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | PP30-36 |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. biblio.abstract | Cimetidine is an orally administered anti-ulcer medication. This study aims to develop a gastro-retentive in situ gel containing the drug to enhance its oral bioavailability and provide prolonged release. The gel was prepared by incorporating an emulsion into a polymeric solution, resulting in a floating in situ gel. The prepared solution was evaluated for pH, viscosity, drug content and in vitro drug release. The in vitro drug release studies demonstrated good drug release, ranging from 61.64% to 84.4% over 10 h. The best formulation, identified as F4, exhibited an in vitro drug release, of 68.64%. The correlation coefficient values from kinetic equations indicated that drug release from the formulations followed a Higuchi first-order release mechanism. The approved formulations met all the criteria for developing a gastro-retentive in situ gel system that gelled quickly and floated within the stomach’s pH range. |
| 654 ## - SUBJECT ADDED ENTRY--FACETED TOPICAL TERMS | |
| Subject | <a href="floating in situ gel">floating in situ gel</a> |
| -- | <a href="targeted drug delivery ">targeted drug delivery </a> |
| -- | <a href="climetidine ">climetidine </a> |
| -- | <a href="sodium alginate ">sodium alginate </a> |
| -- | <a href="xanthan gum ">xanthan gum </a> |
| -- | <a href="gellan gum ">gellan gum </a> |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Sheeba F. Roseleta |
| -- | Navyashree Gowdaa |
| 773 0# - HOST ITEM ENTRY | |
| Host Biblionumber | 125265 |
| Host Itemnumber | 112812 |
| Place, publisher, and date of publication | Mumbai Indian Drugs Manufacturer's Association |
| Title | Indian Drugs |
| International Standard Serial Number | 0019-462X |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Koha item type | Journal Article |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Location (home branch) | Sublocation or collection (holding branch) | Date acquired | Koha issues (times borrowed) | Piece designation (barcode) | Koha date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | SNDT Juhu | SNDT Juhu | 04/07/2025 | jp745.2 | 04/07/2025 | 04/07/2025 | Journal Article |