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FORMULATION AND IN VITRO EVALUATION OF SUBLINGUAL TABLETS OF PIROXICAM (Record no. 132134)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 01781nam a2200145 4500 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 250718b |||||||| |||| 00| 0 eng d |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Meghraj Suryawansh |
| 245 ## - TITLE STATEMENT | |
| Title | FORMULATION AND IN VITRO EVALUATION OF SUBLINGUAL TABLETS OF PIROXICAM |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | pp33-40 |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. biblio.abstract | This study focuses on the development and evaluation of sublingual tablets for piroxicam, aiming to enhance its bioavailability and patient compliance. Preformulation studies confirmed the drug’s identity and purity through melting point analysis, UV-Vis spectroscopy and FT-IR, while solubility test highlights its low solubility in water and buffer, but higher solubility in ethanol. Formulation strategies incorporated varying microcrystalline cellulose (MCC) to polymer or to super disintegrant ratios to improve blend flow and compressibility. Among the formulations tested, A4, containing 5% Kyron T-314, emerged as the most optimized formulation, showing the best pre-compression and post-compression characteristics. It demonstrated superior hardness, low friability, rapid wetting and disintegration times, and achieved nearly complete drug release within 9 minutes. Stability studies over three months confirmed that formulation A4 maintained its physical and mechanical properties. Hence, this formulation is considered highly effective for achieving rapid drug release and improved stability, addressing the need for quicker onset of action and enhanced patient adherence. |
| 654 ## - SUBJECT ADDED ENTRY--FACETED TOPICAL TERMS | |
| Subject | <a href="Contact dermatitis">Contact dermatitis</a> |
| -- | <a href="Sevyachanadi lepa">Sevyachanadi lepa</a> |
| -- | <a href="Sparshaja visha">Sparshaja visha</a> |
| -- | <a href="Gas chromatography-mass spectrometry analysis">Gas chromatography-mass spectrometry analysis</a> |
| -- | <a href="anti-inflammatory ">anti-inflammatory </a> |
| -- | <a href="antioxidant ">antioxidant </a> |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Jailani S |
| 773 0# - HOST ITEM ENTRY | |
| Host Biblionumber | 125265 |
| Host Itemnumber | 112973 |
| Place, publisher, and date of publication | Mumbai Indian Drugs Manufacturer's Association |
| Title | Indian Drugs |
| International Standard Serial Number | 0019-462X |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Koha item type | Journal Article |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Location (home branch) | Sublocation or collection (holding branch) | Date acquired | Koha issues (times borrowed) | Piece designation (barcode) | Koha date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | SNDT Juhu | SNDT Juhu | 18/07/2025 | jp758.2 | 18/07/2025 | 18/07/2025 | Journal Article |