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PHYTOCHEMICALS FROM WITHANIA SOMNIFERA AS A NOVEL STRATEGY AGAINST ANTIBIOTIC RESISTANT PSEUDOMONAS AERUGINOSA (Record no. 132136)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 01821nam a2200145 4500 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 250718b |||||||| |||| 00| 0 eng d |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Akhilesh P. Naik |
| 245 ## - TITLE STATEMENT | |
| Title | PHYTOCHEMICALS FROM WITHANIA SOMNIFERA AS A NOVEL STRATEGY AGAINST ANTIBIOTIC RESISTANT PSEUDOMONAS AERUGINOSA |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | pp49-59 |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. biblio.abstract | Antibiotic overuse has accelerated antimicrobial resistance (AMR), posing significant health and environmental risks. This study investigates the potential of Withania somnifera (Ashwagandha) in combating AMR in Pseudomonas aeruginosa, which exhibits resistance to certain aminoglycoside antibiotics. Disc diffusion assays across 14 antibiotics identified resistance exclusively to gentamicin. Phytochemicals from various parts of Ashwagandha were tested against resistant P. aeruginosa strains. Molecular docking of 68 phytochemicals against MexZ and aminoglycoside 3’-N-acetyltransferase proteins identified lead compounds, while molecular dynamics simulations of MexZ with withaferin A and withanolide B assessed the stability of protein-ligand complexes. The methanolic root extract proved most effective, producing a 34 mm inhibition zone. Molecular docking revealed binding affinities below –8.0 kcal mol-1 in multiple compounds, with key stability parameters from Molecular docking simulation supporting the potential for drug design. The findings highlight Ashwagandha root phytochemicals as promising candidates for overcoming antibiotic resistance in P. aeruginosa. |
| 654 ## - SUBJECT ADDED ENTRY--FACETED TOPICAL TERMS | |
| Subject | <a href="Pseudomonas aeruginosa">Pseudomonas aeruginosa</a> |
| -- | <a href="withania somnifera">withania somnifera</a> |
| -- | <a href="Phytochemicals">Phytochemicals</a> |
| -- | <a href="Molecular docking ">Molecular docking </a> |
| -- | <a href="Molecular dynamics simulation ">Molecular dynamics simulation </a> |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Deeksha Prakasha |
| 773 0# - HOST ITEM ENTRY | |
| Host Biblionumber | 132135 |
| Host Itemnumber | 113083 |
| Main entry heading | Dhanashri S. Dhavale |
| Title | PHYTOCHEMICAL PROFILING AND GC-MS ANALYSIS OF AQUEOUS METHANOL FRACTION OF SEVYACHANDANADI LEPA |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Koha item type | Journal Article |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Location (home branch) | Sublocation or collection (holding branch) | Date acquired | Koha issues (times borrowed) | Piece designation (barcode) | Koha date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | SNDT Juhu | SNDT Juhu | 18/07/2025 | jp758.4 | 18/07/2025 | 18/07/2025 | Journal Article |