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Chemically standardised extract of Withania somnifera (Ashwagandha) inhibits tumour growth, promotes apoptosis and cell cycle arrest (Record no. 132358)
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| fixed length control field | 02289nam a2200145 4500 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
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| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Subasini Uthirapathy |
| 245 ## - TITLE STATEMENT | |
| Title | Chemically standardised extract of Withania somnifera (Ashwagandha) inhibits tumour growth, promotes apoptosis and cell cycle arrest |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | pp236-245 |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. biblio.abstract | Withania somnifera Dunal (Family: Solanaceae), also known as ashwagandha, is indigenous to Asia and Africa. It is also known as "Indian Ginseng." It has been used for thousands of years in ancient Indian Ayurvedic medicine to reduce stress and pain, increase energy, improve nutrition, and treat various health conditions. The present study aims to determine the chemopreventive potential of a chemically standardised extract of W. somnifera against lung cancer (A549) and breast cancer (MCF-7) cell lines. The anticancer activity of W. somnifera was determined against lung and breast cancer using A549 and MCF-7 cell lines, respectively, in different anticancer models, and the chemical constituent was determined by the GC-MS method. After being treated for 48 hours in MTT assay, W. somnifera successfully reduced the viability of the MCF-7 cell line with an IC50 value of 41.83 μg/mL in a dose-dependent manner. W. somnifera extract treatment reduced cyclin D1 and E2 expression in A549 cell lines. It was correlated to cell cycle arrest in the G0/G1 phase. Additionally, it decreased nuclear factor β-translocation, a pro-survival signal. In the human lung cancer cell line (A459), the anticancer activity was evaluated by Cas 3 gene expression investigation by RT-PCR. The existence of fatty acids in higher concentrations was revealed by GC-MS analysis of the methanolic fraction from the 70% ethanolic extract of W. somnifera, which produced 28 compounds. Given its apoptogenic and antiproliferative qualities, the observations point to the chemopreventive potential of W. somnifera extract. Additional research is required to investigate these effects in in vivo models. |
| 654 ## - SUBJECT ADDED ENTRY--FACETED TOPICAL TERMS | |
| Subject | <a href=" A549 cells"> A549 cells</a> |
| -- | <a href="Breast cancer">Breast cancer</a> |
| -- | <a href="GC-MS, Lung carcinoma">GC-MS, Lung carcinoma</a> |
| -- | <a href="MCF-7 cells">MCF-7 cells</a> |
| -- | <a href="Withania somnifera">Withania somnifera</a> |
| -- | <a href="MTT assa">MTT assa</a> |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Javed Ahamad |
| 773 0# - HOST ITEM ENTRY | |
| Host Biblionumber | 125285 |
| Host Itemnumber | 113116 |
| Place, publisher, and date of publication | New Delhi NISCAIR |
| Title | Indian Journal of Natural Products and Resources |
| International Standard Serial Number | 0976-0504 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Koha item type | Journal Article |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Location (home branch) | Sublocation or collection (holding branch) | Date acquired | Koha issues (times borrowed) | Piece designation (barcode) | Koha date last seen | Price effective from | Koha item type |
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| Dewey Decimal Classification | SNDT Juhu | SNDT Juhu | 05/08/2025 | jp801.1 | 05/08/2025 | 05/08/2025 | Journal Article |