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Enhancement of metformin bioavailability by Tinospora cordifolia extracts: Insights into pharmacokinetic interactions (Record no. 132360)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 01630nam a2200145 4500 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 250805b |||||||| |||| 00| 0 eng d |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Rajanikanta Sahu |
| 245 ## - TITLE STATEMENT | |
| Title | Enhancement of metformin bioavailability by Tinospora cordifolia extracts: Insights into pharmacokinetic interactions |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | pp258-270 |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. biblio.abstract | Tinospora cordifolia aqua-alcoholic extract (TCE) with metformin (MET) has been shown to be significantly more effective against clinical diabetes-associated disorders. Since there is insufficient clarity behind this, pharmacokinetic interaction was investigated to unravel the mechanism partly. A significant increase in area under the curve (AUC0-∞), half-life (T1/2), and decrease in renal clearance (CLr) of MET was observed in animals dosed with TCE (100 mg/Kg) for 14 days. However, no significant change was observed in the time to reach maximum concentration (Tmax), indicating that TCE selectively affects the CLr of MET. Many TCE’s cationic components/metabolites showed a relatively higher potential affinity for organic cationic transporter 2 (OCT2), which partly justifies the selective pharmacokinetic interaction of MET with TCE. In conclusion, TCE enhances the bioavailability of MET by reducing its renal clearance. This partly explains the basis of TCE as a complementary therapy, which requires further validation. |
| 654 ## - SUBJECT ADDED ENTRY--FACETED TOPICAL TERMS | |
| Subject | <a href="Herb-drug interactions">Herb-drug interactions</a> |
| -- | <a href="LC-MS, Metformin">LC-MS, Metformin</a> |
| -- | <a href="Pharmacokinetic">Pharmacokinetic</a> |
| -- | <a href="Tinospora cordifolia">Tinospora cordifolia</a> |
| -- | <a href="Type 2 diabetes">Type 2 diabetes</a> |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mahendra Gaur |
| 773 0# - HOST ITEM ENTRY | |
| Host Biblionumber | 125285 |
| Host Itemnumber | 113116 |
| Place, publisher, and date of publication | New Delhi NISCAIR |
| Title | Indian Journal of Natural Products and Resources |
| International Standard Serial Number | 0976-0504 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Koha item type | Journal Article |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Location (home branch) | Sublocation or collection (holding branch) | Date acquired | Koha issues (times borrowed) | Piece designation (barcode) | Koha date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | SNDT Juhu | SNDT Juhu | 05/08/2025 | jp801.3 | 05/08/2025 | 05/08/2025 | Journal Article |