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Evaluation of the in vivo subacute toxicity of Otolith as a novel traditional hypoglycemic agent (Record no. 132397)
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| 000 -LEADER | |
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| fixed length control field | 01965nam a2200145 4500 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 250806b |||||||| |||| 00| 0 eng d |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Abdullah Ahmed Areqi |
| 245 ## - TITLE STATEMENT | |
| Title | Evaluation of the in vivo subacute toxicity of Otolith as a novel traditional hypoglycemic agent |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | pp536-542 |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. biblio.abstract | In coastal areas like Hodeida governorate-Yemen, otolith, or "ear stone", are used to treat diabetes. Locals believe that these formations can manage diabetes and relieve migraine pain. This study examines the in vivo subacute toxicity and safety of catfish otolith as a novel traditional antidiabetic agent. Twenty \ fourmale rats were evenly divided into four six-rat groups. Control group (Group 1) received 0.9% w/v sodium chloride for 21 days. The remaining three groups received oral otolith at different doses for the same time. Group 2, the low-dose group, received 5 g/day otolith per body weight. Mid-dose group 3 received 10 g/day otolith per body weight. Finally, Group 4, the high-dose group, received 15 g/day otolith per body weight. The animals' behavior and anomalies were recorded throughout the experiment. Biochemical tests like liver and kidney function and hematological tests like total blood count were done at the end of the experiment. In large doses, otoliths reduced cholesterol, LDL, and triglycerides and increased HDL. Otolith did not affect renal function or electrolyte balance at the tested doses. It affected certain hepatic enzyme functions at higher doses, but protein levels remained stable across doses, indicating neither liver injury nor considerable hepatic function loss. This study sheds light on otolith's safety, notably for renal function, electrolyte homeostasis, and liver health. |
| 654 ## - SUBJECT ADDED ENTRY--FACETED TOPICAL TERMS | |
| Subject | <a href="Otolith">Otolith</a> |
| -- | <a href="Safety">Safety</a> |
| -- | <a href="Subacute toxicity">Subacute toxicity</a> |
| -- | <a href="Traditional antidiabetic">Traditional antidiabetic</a> |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Doaa Anwar Ibrahim |
| 773 0# - HOST ITEM ENTRY | |
| Host Biblionumber | 125286 |
| Host Itemnumber | 113119 |
| Place, publisher, and date of publication | New Delhi NISCAIR |
| Title | Indian Journal of Traditional Knowledge |
| International Standard Serial Number | 0972-5938 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Koha item type | Journal Article |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Location (home branch) | Sublocation or collection (holding branch) | Date acquired | Koha issues (times borrowed) | Piece designation (barcode) | Koha date last seen | Price effective from | Koha item type |
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| Dewey Decimal Classification | SNDT Juhu | SNDT Juhu | 06/08/2025 | jp804.3 | 06/08/2025 | 06/08/2025 | Journal Article |