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ETODOLAC LOADED MESOPOROUS SILICA NANOPARTICLES BASED TOPICAL GEL FOR TREATMENT OF INFLAMMATION (Record no. 132518)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 01625nam a2200133 4500 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 250821b |||||||| |||| 00| 0 eng d |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Jayesh R. Guptaa, |
| 245 ## - TITLE STATEMENT | |
| Title | ETODOLAC LOADED MESOPOROUS SILICA NANOPARTICLES BASED TOPICAL GEL FOR TREATMENT OF INFLAMMATION |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | Page No. 28-36 |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. biblio.abstract | This study explores a topical hydrogel incorporating mesoporous silica nanoparticles (MSNs) loaded with etodolac (ETD) for inflammation treatment. MSNs were synthesized via the sol-gel method and loaded with ETD using adsorption. The ETD-MSNs were formulated into a gel using Carbopol® Ultrez. Characterization confirmed an average size of 254.9 nm, a zeta potential of -38mV, and high porosity. The encapsulation and loading efficiencies were 23.92 % and 28.12 %, respectively. In vitro drug release showed 93.60±1.31 % cumulative release at 8 h. In vivo studies in a Complete Freund’s Adjuvant (CFA) induced arthritic rat model demonstrated significant reduction in inflammation, articular damage and pannus formation. The gel outperformed marketed Proxym® gel in reducing paw edema. Stability studies confirmed no significant changes over 3 months. These findings highlight the potential of ETD-MSN hydrogel as an effective anti-inflammatory treatment with sustained drug release and enhanced therapeutic efficacy. |
| 654 ## - SUBJECT ADDED ENTRY--FACETED TOPICAL TERMS | |
| Subject | <a href="Computer aided drug desingn">Computer aided drug desingn</a> |
| -- | <a href="molecular docking ">molecular docking </a> |
| -- | <a href="SARS-CoV-2 main protease ">SARS-CoV-2 main protease </a> |
| -- | <a href="Tinospora sinensis">Tinospora sinensis</a> |
| -- | <a href="Autodock vina">Autodock vina</a> |
| -- | <a href="antiviral phytoconstituents">antiviral phytoconstituents</a> |
| 773 0# - HOST ITEM ENTRY | |
| Host Biblionumber | 125265 |
| Host Itemnumber | 113416 |
| Place, publisher, and date of publication | Mumbai Indian Drugs Manufacturer's Association |
| Title | Indian Drugs |
| International Standard Serial Number | 0019-462X |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Koha item type | Journal Article |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Location (home branch) | Sublocation or collection (holding branch) | Date acquired | Koha issues (times borrowed) | Piece designation (barcode) | Koha date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | SNDT Juhu | SNDT Juhu | 21/08/2025 | jp839.2 | 21/08/2025 | 21/08/2025 | Journal Article |