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DEVELOPMENT AND OPTIMIZATION OF A QUALITY BY DESIGN-DRIVEN HPLC METHOD FOR CURCUMIN QUANTIFICATION (Record no. 132519)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 01492nam a2200145 4500 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 250821b |||||||| |||| 00| 0 eng d |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Saurabh Morpariaa |
| 245 ## - TITLE STATEMENT | |
| Title | DEVELOPMENT AND OPTIMIZATION OF A QUALITY BY DESIGN-DRIVEN HPLC METHOD FOR CURCUMIN QUANTIFICATION |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | Page No. 37-44 |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. biblio.abstract | The research study involves development and validation of a robust RP-HPLC technique for curcumin quantification using Analytical Quality by Design (AQbD). Key method parameters such as composition of mobile phase, temperature of column, and flow rate were optimized using a 33 -level factorial design. The method performance was evaluated based on chromatographic attributes, which include number of theoretical plates, peak area, retention time, and height equivalent to a theoretical plate. Various optimal conditions were identified within the experimental space through numerical and graphical analysis. Validation confirmed high accuracy and precision, with recoveries between 98.23% and 101.37% and RSD within ±2%. The method showed a linear relationship between curcumin concentration (5-25 µg mL-1) and detector response. Sensitivity assessment revealed detection and quantification limits of 1.16 µg mL-1 and 0.38 µg mL-1, respectively. |
| 654 ## - SUBJECT ADDED ENTRY--FACETED TOPICAL TERMS | |
| Subject | <a href="HPLC">HPLC</a> |
| -- | <a href="AQbD">AQbD</a> |
| -- | <a href="Validation">Validation</a> |
| -- | <a href="curcumin ">curcumin </a> |
| -- | <a href="robust">robust</a> |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Chaitanya Methaa |
| 773 0# - HOST ITEM ENTRY | |
| Host Biblionumber | 125265 |
| Host Itemnumber | 113416 |
| Place, publisher, and date of publication | Mumbai Indian Drugs Manufacturer's Association |
| Title | Indian Drugs |
| International Standard Serial Number | 0019-462X |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Koha item type | Journal Article |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Location (home branch) | Sublocation or collection (holding branch) | Date acquired | Koha issues (times borrowed) | Piece designation (barcode) | Koha date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | SNDT Juhu | SNDT Juhu | 21/08/2025 | jp839.3 | 21/08/2025 | 21/08/2025 | Journal Article |