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Article Details COMPARATIVE ASSESSMENT OF THE BIOACTIVE POTENTIAL OF PIMENTA DIOICA STEM EXTRACTS: ANTIOXIDANT AND ANTI-PROLIFERATIVE PROPERTIES (Record no. 132522)
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| fixed length control field | 02910nam a2200145 4500 |
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| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Irfana M. K |
| 245 ## - TITLE STATEMENT | |
| Title | Article Details COMPARATIVE ASSESSMENT OF THE BIOACTIVE POTENTIAL OF PIMENTA DIOICA STEM EXTRACTS: ANTIOXIDANT AND ANTI-PROLIFERATIVE PROPERTIES |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | Page No. 50-56This research explores the antioxidative effects and anti-proliferative action of Pimenta dioica stem extracts. The ethanolic and aqueous extracts were evaluated for their ability to neutralize DPPH radicals, reduce ferric ions, scavenge hydrogen peroxide and exhibit cytotoxic effects on cancer cell lines. The ethanolic extract showed superior DPPH radical scavenging activity (92.36±0.18% inhibition) compared to the aqueous extract (31.76±0.46%). Additionally, the ethanolic extract demonstrated higher ferric-reducing antioxidant power (90.86±0.10%) than the aqueous extract (82.32±0.15%). While both extracts scavenged hydrogen peroxide, the aqueous extract was more effective (28.15±5.09%). The aqueous extract had superior activity (96.22±0.09%) compared to the ethanolic extract in the reducing power assay. Cytotoxicity was evaluated for both extracts in the L929 cell line, and the anti-proliferative study displayed a concentration-responsive action against the SKOV-3 cell line. These findings indicate that P. dioica extracts have notable antioxidant and enhanced anti-proliferative effects against ovarian cancer cells. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. biblio.abstract | This research explores the antioxidative effects and anti-proliferative action of Pimenta dioica stem extracts. The ethanolic and aqueous extracts were evaluated for their ability to neutralize DPPH radicals, reduce ferric ions, scavenge hydrogen peroxide and exhibit cytotoxic effects on cancer cell lines. The ethanolic extract showed superior DPPH radical scavenging activity (92.36±0.18% inhibition) compared to the aqueous extract (31.76±0.46%). Additionally, the ethanolic extract demonstrated higher ferric-reducing antioxidant power (90.86±0.10%) than the aqueous extract (82.32±0.15%). While both extracts scavenged hydrogen peroxide, the aqueous extract was more effective (28.15±5.09%). The aqueous extract had superior activity (96.22±0.09%) compared to the ethanolic extract in the reducing power assay. Cytotoxicity was evaluated for both extracts in the L929 cell line, and the anti-proliferative study displayed a concentration-responsive action against the SKOV-3 cell line. These findings indicate that P. dioica extracts have notable antioxidant and enhanced anti-proliferative effects against ovarian cancer cells. |
| 654 ## - SUBJECT ADDED ENTRY--FACETED TOPICAL TERMS | |
| Subject | <a href="Pimenta dioica">Pimenta dioica</a> |
| -- | <a href="anti-proliferative ">anti-proliferative </a> |
| -- | <a href="antioxidant">antioxidant</a> |
| -- | <a href="cell line">cell line</a> |
| -- | <a href="ovarian cancer ">ovarian cancer </a> |
| -- | <a href="cytotoxicity">cytotoxicity</a> |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Jayasheela Da |
| 773 0# - HOST ITEM ENTRY | |
| Host Biblionumber | 125265 |
| Host Itemnumber | 113416 |
| Place, publisher, and date of publication | Mumbai Indian Drugs Manufacturer's Association |
| Title | Indian Drugs |
| International Standard Serial Number | 0019-462X |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Koha item type | Journal Article |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Location (home branch) | Sublocation or collection (holding branch) | Date acquired | Koha issues (times borrowed) | Piece designation (barcode) | Koha date last seen | Price effective from | Koha item type |
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| Dewey Decimal Classification | SNDT Juhu | SNDT Juhu | 21/08/2025 | jp839.5 | 21/08/2025 | 21/08/2025 | Journal Article |