SNDT WOMEN'S UNIVERSITY
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Association of RANK gene variants with its circulatory level and bone mineral density in postmenopausal women with and without osteoporosis (Record no. 132596)
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| 000 -LEADER | |
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| fixed length control field | 01866nam a2200145 4500 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 250826b |||||||| |||| 00| 0 eng d |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Priya Dixit1 |
| 245 ## - TITLE STATEMENT | |
| Title | Association of RANK gene variants with its circulatory level and bone mineral density in postmenopausal women with and without osteoporosis |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | pp1200-1209 |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. biblio.abstract | The present study aims to explore the possible association pattern of receptor activator of nuclear factor kappa B (RANK) gene variants (rs 35211496 and<br/>rs 1805034) with its circulatory level and bone mineral density (BMD) in North Indian postmenopausal<br/>women. In this case-control study, we recruited 165<br/>postmenopausal osteoporotic women as cases (age<br/>54.44 ± 6.00) and 165 healthy postmenopausal women<br/>as controls (age 54.47 ± 6.46). BMDs were taken in<br/>all subjects using dual energy X-ray absorptiometry<br/>at different skeletal sites, and genotyping was carried<br/>out using polymerase chain reaction and the restriction fragment length polymorphism method. RANK<br/>serum levels were also assessed in all enrolled subjects by enzyme-linked immunosorbent assay. Findings from the present study indicated that subjects<br/>with homozygous mutant TT genotype of rs35211496<br/>(NC_000018.10 : g.62354528C > T) and rs1805034<br/>(NC_000018.10 : g.62360008C > T) showed significantly<br/>low BMD at forearm, lumbar spine, hip and femoral<br/>neck and increased RANK level as compared to CC<br/>and CT genotypes. Furthermore, at rs1805034, a<br/>significant difference was noted in the frequency<br/>of RANK genotypes and alleles among osteoporotic<br/>cases and controls (P = 0.021; 0.005) respectively |
| 654 ## - SUBJECT ADDED ENTRY--FACETED TOPICAL TERMS | |
| Subject | <a href="BMD">BMD</a> |
| -- | <a href="haplotype">haplotype</a> |
| -- | <a href="osteoporosis">osteoporosis</a> |
| -- | <a href="receptor activator of nuclear factor κ B">receptor activator of nuclear factor κ B</a> |
| -- | <a href="receptor activator of nuclear factor kappa-B ligand">receptor activator of nuclear factor kappa-B ligand</a> |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Israr Ahmad1 |
| 773 0# - HOST ITEM ENTRY | |
| Host Biblionumber | 125299 |
| Host Itemnumber | 113183 |
| Title | Current Science |
| International Standard Serial Number | 0011-3891 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Koha item type | Journal Article |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Location (home branch) | Sublocation or collection (holding branch) | Date acquired | Koha issues (times borrowed) | Piece designation (barcode) | Koha date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | SNDT Juhu | SNDT Juhu | 26/08/2025 | jp826.3 | 26/08/2025 | 26/08/2025 | Journal Article |