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Hemidesmus indicus Linn. extract protects multiple organ injury due to its pharmacologically suitable physicochemical properties (Record no. 132666)
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| fixed length control field | 02391nam a2200145 4500 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
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| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Monika Bhadauria |
| 245 ## - TITLE STATEMENT | |
| Title | Hemidesmus indicus Linn. extract protects multiple organ injury due to its pharmacologically suitable physicochemical properties |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | PP686-697 |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. biblio.abstract | Hemidesmus indicus Linn. is used in the Ayurveda system of medicine in India. Co-exposure to D-galactosamine and lipopolysaccharide is employed in experiments to mimics human viral hepatitis in rats but also damages other organs as D-galactosamine depletes uridine triphosphate pool and inhibits protein synthesis, whereas lipopolysaccharide induces inflammation. We investigated physicochemical properties of extract of Hemidesmus indicus root and its protective potential against multiple organ injury in rats. Doses of Hemidesmus indicus (50, 100 and 200 mg/ kg) were orally administered to different groups of rats before co-exposure to D-galactosamine (300 mg/kg) and lipopolysaccharide (50 µg/kg) intraperitoneally. Hematology, serology, and tissue biochemistry were performed. Aspartate aminotransferase, alanine aminotransferase, bilirubin, cholesterol, urea, uric acid, and creatinine were increased in serum; aniline hydroxylase, lipid peroxidation and cholesterol level in liver, kidney, brain, testis, and spleen tissues were increased. Serum albumin, glucose, and red blood cells; superoxide dismutase, catalase, and glycogen in tissues were decreased after co-exposure to D-galactosamine and lipopolysaccharide. Physicochemical characterization indicated particle size of extract about 43 nm, presence of caffeic acid, quercetin, naringenin and trans-cinnamic acid, and presence of carboxylic acid, aromatic compounds, alkenyl and alkyl groups, alkenes and atmospheric CO2 in Hemidesmus indicus root extract. It was concluded that prophylactic treatment of root extract of Hemidesmus indicus root extract protects multiple organs from injury in dose dependent manner by maintaining diagnostic indices towards control due to its excellent antioxidant potential. |
| 654 ## - SUBJECT ADDED ENTRY--FACETED TOPICAL TERMS | |
| Subject | <a href="Antioxidant potential">Antioxidant potential</a> |
| -- | <a href="D-galactosamine">D-galactosamine</a> |
| -- | <a href="Hemidesmus indicus">Hemidesmus indicus</a> |
| -- | <a href="Lipopolysaccharide">Lipopolysaccharide</a> |
| -- | <a href=" Physicochemical characterization"> Physicochemical characterization</a> |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Asim Amitabh Sahu |
| 773 0# - HOST ITEM ENTRY | |
| Host Biblionumber | 125286 |
| Host Itemnumber | 113533 |
| Place, publisher, and date of publication | New Delhi NISCAIR |
| Title | Indian Journal of Traditional Knowledge |
| International Standard Serial Number | 0972-5938 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Koha item type | Journal Article |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Location (home branch) | Sublocation or collection (holding branch) | Date acquired | Koha issues (times borrowed) | Piece designation (barcode) | Koha date last seen | Price effective from | Koha item type |
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| Dewey Decimal Classification | SNDT Juhu | SNDT Juhu | 30/08/2025 | jp887.8 | 30/08/2025 | 30/08/2025 | Journal Article |