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Association Between Maternal Prepregnancy and Pregnancy Body Mass Index and Children's Telomere Length: A Systematic Review and Meta-analysis (Record no. 132761)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02013nam a2200145 4500 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 250911b |||||||| |||| 00| 0 eng d |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Amir Hossein Lame-Jouybari |
| 245 ## - TITLE STATEMENT | |
| Title | Association Between Maternal Prepregnancy and Pregnancy Body Mass Index and Children's Telomere Length: A Systematic Review and Meta-analysis |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | PP622–635 |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. biblio.abstract | Context<br/>Telomeres maintain chromosome stability and mark cellular aging, and their shortening with age compromises genomic stability.<br/><br/>Objective<br/>The purpose of this study was to conduct a meta-analysis of existing evidence to evaluate the relationship between the maternal pregnancy body mass index (BMI) and children's telomere length (TL).<br/><br/>Data Source<br/>Web of Science, Scopus, and PubMed databases were systematically searched from their inception to August 27, 2023, for pertinent observational studies.<br/><br/>Data Extraction<br/>The random-effects meta-analysis was conducted on eligible studies that investigated the linear relationship between exposure and the outcomes of interest, utilizing the reported β-coefficient. Cochran’s Q test and I2 statistics were used to assess heterogeneity.<br/><br/>Data Analysis<br/>A significant association was observed between maternal pregnancy BMI and children's TL (32 studies, pooled effect size [ES]: −0.04; 95% CI: −0.06 to −0.01; I2 = 47.51%, P < .001) and maternal prepregnancy BMI and children's TL at birth (16 studies; pooled ES: −0.05; 95% CI: −0.08 to −0.02; I2 = 53.49%, P < .001).<br/><br/>Conclusion<br/>The findings indicate an inverse association between maternal prepregnancy BMI and TL in infants, which is evident within the normal to obese BMI range. This underscores the significance of maternal weight status before pregnancy as a determinant of offspring TL |
| 654 ## - SUBJECT ADDED ENTRY--FACETED TOPICAL TERMS | |
| Subject | <a href="birth telomere length">birth telomere length</a> |
| -- | <a href=" prepregnancy BMI"> prepregnancy BMI</a> |
| -- | <a href="maternal weight">maternal weight</a> |
| -- | <a href=" offspring"> offspring</a> |
| -- | <a href="meta-analysis">meta-analysis</a> |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mohammad Salar Fahami |
| 773 0# - HOST ITEM ENTRY | |
| Host Biblionumber | 25311 |
| Host Itemnumber | 113491 |
| Place, publisher, and date of publication | 2009 |
| Title | Nutrition Reviews |
| International Standard Serial Number | 0029-6643 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Koha item type | Journal Article |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Location (home branch) | Sublocation or collection (holding branch) | Date acquired | Koha issues (times borrowed) | Piece designation (barcode) | Koha date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | SNDT Juhu | SNDT Juhu | 11/09/2025 | JP871.3 | 11/09/2025 | 11/09/2025 | Journal Article |