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The Metabolic Characteristics and Bioavailability of Resveratrol Based on Metabolic Enzymes (Record no. 132771)
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| 000 -LEADER | |
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| fixed length control field | 01772nam a2200145 4500 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 250911b |||||||| |||| 00| 0 eng d |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Yang Yang |
| 245 ## - TITLE STATEMENT | |
| Title | The Metabolic Characteristics and Bioavailability of Resveratrol Based on Metabolic Enzymes |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | pp749–770 |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. biblio.abstract | The natural polyphenol resveratrol (RV) has garnered fame for its extensive pharmacological properties. Although clinical studies have shown some positive results, many contradictory outcomes remain. An important obstacle to the development of therapeutic applications for RV is its low bioavailability in vivo. This may be partially attributed to biotransformation mediated by phase I and II enzymes, such as cytochrome P450s, UDP-glucuronosyltransferases, and sulfotransferases. To date, more than 20 different types of metabolites have been detected after catalysis by these enzymes. Notably, RV and some of its metabolites serve as substrates for these enzymes. Conversely, RV can directly regulate the expression or activity of these enzymes. Given the increasing number of studies investigating the bioactivity of RV, this review summarizes its physicochemical and pharmacokinetic characteristics and describes the metabolism of RV and the bioactivities of its metabolites, with emphasis on the interaction between RV and its related metabolic enzymes. In addition to hepatic metabolism, the crucial roles of RV metabolism in multiple other tissues and organs cannot be overlooked, and they reveal the relationship between RV metabolism and its biological potential. |
| 654 ## - SUBJECT ADDED ENTRY--FACETED TOPICAL TERMS | |
| Subject | <a href="resveratrol">resveratrol</a> |
| -- | <a href=" pharmacokinetics"> pharmacokinetics</a> |
| -- | <a href=" metabolic enzymes"> metabolic enzymes</a> |
| -- | <a href="metabolites">metabolites</a> |
| -- | <a href="biological activity">biological activity</a> |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Yan Sun |
| 773 0# - HOST ITEM ENTRY | |
| Host Biblionumber | 25311 |
| Host Itemnumber | 113491 |
| Place, publisher, and date of publication | 2009 |
| Title | Nutrition Reviews |
| International Standard Serial Number | 0029-6643 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Koha item type | Journal Article |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Location (home branch) | Sublocation or collection (holding branch) | Date acquired | Koha issues (times borrowed) | Piece designation (barcode) | Koha date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | SNDT Juhu | SNDT Juhu | 11/09/2025 | jp871.11 | 11/09/2025 | 11/09/2025 | Journal Article |