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Effect of Saffron (Crocus sativus) Supplementation on Oxidative Stress, Inflammatory Indices, and Renal and Liver Function Parameters in Patients With Type 2 Diabetes Mellitus: A GRADE-Assessed Systematic Review and Meta-analysis of Randomized Clinical Trials (Record no. 132779)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02881nam a2200145 4500 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 250911b |||||||| |||| 00| 0 eng d |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Alireza Mafi |
| 245 ## - TITLE STATEMENT | |
| Title | Effect of Saffron (Crocus sativus) Supplementation on Oxidative Stress, Inflammatory Indices, and Renal and Liver Function Parameters in Patients With Type 2 Diabetes Mellitus: A GRADE-Assessed Systematic Review and Meta-analysis of Randomized Clinical Trials |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | pp 971–987 |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. biblio.abstract | Context<br/>Clinical investigation has shown that the addition of saffron or crocin to standard antidiabetic medications improves a patient's metabolic profile, oxidative stress (OS), and inflammatory response. Despite a large number of studies examining the impact of saffron supplementation on OS, inflammation, and renal and liver function parameters, no systematic review or meta-analysis has been conducted to compile the outcomes in patients with type 2 diabetes mellitus (T2DM).<br/><br/>Objective<br/>The current systematic review and meta-analysis was performed to investigate the effect of saffron or crocin intake on OS, inflammation, and renal and liver function parameters in patients with T2DM.<br/><br/>Data Sources<br/>Online databases including PubMed, Scopus, ISI Web of Science, and Cochrane Library were searched up to December 2023.<br/><br/>Data Extraction<br/>The mean differences and their respective SDs were extracted. Using a random-effects model, the pooled data were calculated as standardized mean difference (SMD) with 95% CI.<br/><br/>Data Analysis<br/>17 eligible randomized controlled trials were included in this meta-analysis. The pooled findings showed that saffron supplementation remarkably decreased the levels of tumor necrosis factor-α (SMD: −0.37; 95% CI: −0.69 to −0.05; I2 = 40.77%, P = .15), interleukin-6 (IL-6) (SMD: −0.38; 95% CI: −0.65 to −0.10; I2 = 0%, P = .68), and malondialdehyde (MDA) (SMD: −0.36; 95% CI: −0.65 to -0.07; I2= 20.51%, P = .02) compared with the control. In addition, based on subgroup analyses, taking ≥100 mg of saffron daily in individuals with T2DM reduced the serum levels of IL-6 (SMD: −0.50; 95% CI: −0.90 to −0.10; I2 = 0%, P = .50) and MDA (SMD: −0.36; 95% CI: −0.68 to -0.03; I2 = 0, P = .97). Furthermore, the level of alanine transaminase was decreased (SMD: -0.43; 95% CI: −0.73 to −0.12; I2 = 0, P = .66) with a treatment period of <60 days of saffron or crocin supplementation.<br/><br/>Conclusion<br/>Larger studies with more follow-up and higher doses of both saffron and crocin are needed in order to understand the efficacy and safety of these herbs for long-term use as routine therapies.<br/><br/> |
| 654 ## - SUBJECT ADDED ENTRY--FACETED TOPICAL TERMS | |
| Subject | <a href="saffron">saffron</a> |
| -- | <a href=" crocin"> crocin</a> |
| -- | <a href="oxidative stress">oxidative stress</a> |
| -- | <a href="inflammation">inflammation</a> |
| -- | <a href=" liver"> liver</a> |
| -- | <a href="renal">renal</a> |
| -- | <a href=" meta-analysis"> meta-analysis</a> |
| -- | <a href="diabetes">diabetes</a> |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Zeinab Mokhtari |
| 773 0# - HOST ITEM ENTRY | |
| Host Biblionumber | 25311 |
| Host Itemnumber | 113494 |
| Place, publisher, and date of publication | 2009 |
| Title | Nutrition Reviews |
| International Standard Serial Number | 0029-6643 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Koha item type | Journal Article |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Location (home branch) | Sublocation or collection (holding branch) | Date acquired | Koha issues (times borrowed) | Piece designation (barcode) | Koha date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | SNDT Juhu | SNDT Juhu | 11/09/2025 | JP873.1 | 11/09/2025 | 11/09/2025 | Journal Article |