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The Weight of Nutrition on Post-Resection Oncologic Morbidity and Mortality: A Systematic Review and Meta-Analysis of Nutritional Indices (Record no. 132780)

MARC details
000 -LEADER
fixed length control field 02783nam a2200145 4500
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION
fixed length control field 250911b |||||||| |||| 00| 0 eng d
100 ## - MAIN ENTRY--PERSONAL NAME
Personal name Katherine Pierce
245 ## - TITLE STATEMENT
Title The Weight of Nutrition on Post-Resection Oncologic Morbidity and Mortality: A Systematic Review and Meta-Analysis of Nutritional Indices
300 ## - PHYSICAL DESCRIPTION
Extent Pages 988–1005
520 ## - SUMMARY, ETC.
Summary, etc. biblio.abstract Context<br/>Nutritional status is a critical factor in the selection of patients for solid tumor resection. A variety of indices have been developed to quantify nutritional status, and they have differing degrees of predictive power for various postoperative outcomes.<br/><br/>Objective<br/>This study aimed to comprehensively evaluate the predictive ability of commonly used nutritional indices in relation to postoperative complications (POCs), recurrence-free survival (RFS), and OS.<br/><br/>Data Sources<br/>We performed a systematic review of 14 established nutritional indices from January 2015 to July 2022:<br/><br/>Data Extraction<br/>The primary end point was OS, while the secondary end points were POCs and RFS. A subsequent meta-analysis was performed to further assess the predictive ability of these indices for OS based on general index type, primary tumor site, and the patient’s index status.<br/><br/>Data Analysis<br/>In this evaluation, 38 articles reporting data on 23 970 patients were analyzed, focusing on 14 nutritional indices. The indices were categorized into phenotypic, metabolic, immunologic, and combined types. Patients within the cut-off range of any index were predicted to have lower OS (hazard ratio [HR] 2.14, 95% CI 1.84–2.49, P < .01). Lower gastrointestinal (GI) and “other” sites were less predictive than upper GI primary tumors (HR 1.63, HR 1.82, and HR 2.54, respectively; all with P < .01). Phenotypic indices were less predictive than combined indices (HR 1.73 vs HR 2.47, P < .01). Within the combined category, there was no significant difference in the predictive ability of Prognostic Nutritional Index (PNI) vs Geriatric Nutritional Risk Index (GNRI) vs Controlling Nutritional Index (CONUT) (HR 2.63 vs HR 2.42 vs HR 2.07, P = .07).<br/><br/>Conclusion<br/>The predictive efficacy of a nutritional index was found to be highly dependent on the index type, the primary tumor site, and the outcome of interest. In the context of upper GI resections, nutritional status appeared to be more of a significant predictor of OS, compared with cases involving lower GI and hepatic malignancies. Indices that integrate phenotypic, metabolic, and immunologic patient factors potentially offer greater clinical utility in forecasting OS.
654 ## - SUBJECT ADDED ENTRY--FACETED TOPICAL TERMS
Subject <a href="cancer cachexia">cancer cachexia</a>
-- <a href=" malnutrition"> malnutrition</a>
-- <a href=" sarcopenia"> sarcopenia</a>
700 ## - ADDED ENTRY--PERSONAL NAME
Personal name Jeremy Gaskins
773 0# - HOST ITEM ENTRY
Host Biblionumber 25311
Host Itemnumber 113494
Place, publisher, and date of publication 2009
Title Nutrition Reviews
International Standard Serial Number 0029-6643
942 ## - ADDED ENTRY ELEMENTS (KOHA)
Koha item type Journal Article
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    Dewey Decimal Classification     SNDT Juhu SNDT Juhu 11/09/2025   JP873.2 11/09/2025 11/09/2025 Journal Article