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Prevalence and Metabolic Predictors of Metabolic Dysfunction-Associated Steatotic Liver Disease in Lean Indian Women with Polycystic Ovary Syndrome versus Those with Obesity (Record no. 132801)

MARC details
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fixed length control field 02744nam a2200145 4500
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION
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100 ## - MAIN ENTRY--PERSONAL NAME
Personal name Dr NEKI RAM
245 ## - TITLE STATEMENT
Title Prevalence and Metabolic Predictors of Metabolic Dysfunction-Associated Steatotic Liver Disease in Lean Indian Women with Polycystic Ovary Syndrome versus Those with Obesity
300 ## - PHYSICAL DESCRIPTION
Extent PP11-20
520 ## - SUMMARY, ETC.
Summary, etc. biblio.abstract Metabolic dysfunction-associated steatotic liver disease (MASLD), linked to obesity and insulin resistance (IR),<br/>is common in polycystic ovary syndrome (PCOS), but its prevalence in lean individuals with PCOS is not well-established.<br/>Hence, the aim of the present study is to investigate the prevalence and predictors of MASLD in lean PCOS patients versus<br/>those with obesity. Materials and methods: Fifty premenopausal participants diagnosed with PCOS were divided into two<br/>groups based on their body mass index (BMI): Group A (lean + normal weight, n = 21) and Group B (overweight + obesity,<br/>n = 29). Clinical, anthropometric, and biochemical variables were assessed, including IR, lipid profiles, and hormonal<br/>levels. The prevalence of MASLD was determined using ultrasonography (USG). Statistical analysis: Mean ± SD (standard<br/>deviation) was used for time-varying variables, and percentages for categorical variables. Univariate analysis included<br/>Chi-square and independent t-tests (p < 0.05). Multivariate logistic regression assessed MASLD occurrence in PCOS subjects.<br/>Analysis was conducted using Stata software version 14 IC. Results: The overall prevalence of MASLD was 40%, with a<br/>significantly higher proportion in Group B compared to Group A (62.06% vs. 9.50%; p < 0.001). IR was also more common<br/>in Group B (79.30% vs. 23.80%; p < 0.001). In spite of lower IR, Group A participants also had elevated mean fasting insulin<br/>levels (10.32 ± 7.01 mIU/mL), suggesting early metabolic disturbances. Also, Group B participants had significantly higher<br/>triglycerides (141.24 ± 42.75 vs. 114.10 ± 31.62 mg/dL; p = 0.018), lower high-density lipoprotein cholesterol (43.41 ± 7.57 vs.<br/>51.41 ± 7.12 mg/dL; p < 0.001) and higher prevalence of metabolic syndrome (58.62% vs. 4.70%; p < 0.001) as compared to<br/>Group A participants. Conclusion: Our study shows a high prevalence of MASLD in obese women with PCOS, likely due<br/>to IR. Lean women with PCOS also exhibited metabolic issues, suggesting they may be at risk. These findings highlight the<br/>importance of early metabolic screening and interventions in PCOS women.
654 ## - SUBJECT ADDED ENTRY--FACETED TOPICAL TERMS
Subject <a href="PCOS">PCOS</a>
-- <a href="MASLD">MASLD</a>
-- <a href="fatty liver disease">fatty liver disease</a>
-- <a href="metabolic dysfunction">metabolic dysfunction</a>
700 ## - ADDED ENTRY--PERSONAL NAME
Personal name Dr SAMEER AGGARWAL
773 0# - HOST ITEM ENTRY
Host Biblionumber 125272
Host Itemnumber 113839
Place, publisher, and date of publication India IJCP Publications (P) Ltd.
Title Indian Journal of Clinical Practice
International Standard Serial Number 0971-0876
942 ## - ADDED ENTRY ELEMENTS (KOHA)
Koha item type Journal Article
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    Dewey Decimal Classification     SNDT Juhu SNDT Juhu 12/09/2025   JP927.1 12/09/2025 12/09/2025 Journal Article