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Rediscovering a Forgotten Link: TSPO and RIM-BP1 in Appetite Regulation (Record no. 132816)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 01709nam a2200133 4500 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 250913b |||||||| |||| 00| 0 eng d |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Joshua Wang |
| 245 ## - TITLE STATEMENT | |
| Title | Rediscovering a Forgotten Link: TSPO and RIM-BP1 in Appetite Regulation |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | p961–964 |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. biblio.abstract | The translocator protein of 18 kDa (TSPO) and RIM binding protein 1 (RIM-BP1) are both heavily expressed in neurons at the olfactory bulb. These proteins have overlapping functional profiles and are both implicated in the development of obesity. Over 20 years ago, a yeast 2-hybrid experiment discovered that RIM-BP1 interacts with a peptide constructed from a fraction of the TSPO sequence. Considering these data, the authors predict that the interaction between RIM-BP1 and TSPO could alter the olfactory system’s mediation of appetite. Despite the therapeutic potential of this interaction, it has never been confirmed if the full TSPO protein and RIM-BP1 interact. The interaction is instead often cited as physiologically irrelevant. This commentary revisits the forgotten interaction between TSPO and RIM-BP1, reviewing all relevant literature discussing their relationship. Contrary to common discourse that the RIM-BP1 and TSPO are potential binding partners, while the interaction may regulate many neurological functions, existing evidence suggests that the interaction would have a specific role in odor-guided appetite. Further research into the nutritional neuroscientific consequences of TSPO/RIM-BP1 interactions should therefore be conducted. |
| 654 ## - SUBJECT ADDED ENTRY--FACETED TOPICAL TERMS | |
| Subject | <a href="appetite regulation">appetite regulation</a> |
| -- | <a href="olfaction">olfaction</a> |
| -- | <a href="olfactory bulb">olfactory bulb</a> |
| -- | <a href="TSPO">TSPO</a> |
| -- | <a href="odor-guided eating">odor-guided eating</a> |
| 773 0# - HOST ITEM ENTRY | |
| Host Biblionumber | 25311 |
| Host Itemnumber | 113493 |
| Place, publisher, and date of publication | 2009 |
| Title | Nutrition Reviews |
| International Standard Serial Number | 0029-6643 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Koha item type | Journal Article |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Location (home branch) | Sublocation or collection (holding branch) | Date acquired | Koha issues (times borrowed) | Piece designation (barcode) | Koha date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | SNDT Juhu | SNDT Juhu | 13/09/2025 | JP872.12 | 13/09/2025 | 13/09/2025 | Journal Article |