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MEBENDAZOLE LOADED NANOSPONGES CAPSULES FOR TREATMENT OF WORM INFECTIONS (Record no. 132970)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 01875nam a2200145 4500 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 251003b |||||||| |||| 00| 0 eng d |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Manisha S. Karpe |
| 245 ## - TITLE STATEMENT | |
| Title | MEBENDAZOLE LOADED NANOSPONGES CAPSULES FOR TREATMENT OF WORM INFECTIONS |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | pp18-27 |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. biblio.abstract | Mebendazole (MBZ), an anthelmintic, was incorporated into nanosponges to improve its delivery. The nanosponges were prepared using polyvinyl alcohol (PVA) as an emulsifying agent and ethylene cellulose as a polymer, via emulsion solvent diffusion. The formulation was optimized using Central Composite Design (CCD) and evaluated for various physicochemical properties, including production yield, entrapment efficiency, particle size, zeta potential and in vitro release. Analytical techniques like Fourier Transform Infrared Spectroscopy, Differential Scanning Calorimetry, Field emission scanning electron microscopy (FESEM) and X-ray Diffraction were used for evaluation. The production yield was 91.21 %, and entrapment efficiency was 89.13 %. Characterization confirmed successful encapsulation and nanosponge formation. FESEM showed porous, spherical structures and the zeta potential was +11.2 mV with particle size ranging from 514 nm to 554 nm. The in vitro drug release was 86.66 %, and capsule disintegration and content of active were found to be adequate. Stability studies indicated that the capsules were stable. These results suggest that mebendazole-loaded nanosponges effectively address challenges associated with conventional mebendazole formulations. |
| 654 ## - SUBJECT ADDED ENTRY--FACETED TOPICAL TERMS | |
| Subject | <a href="Mebendazole [MBZ]">Mebendazole [MBZ]</a> |
| -- | <a href="BCS Class II">BCS Class II</a> |
| -- | <a href="Anthelmintic agent">Anthelmintic agent</a> |
| -- | <a href="emulsion solvent evaporation method ">emulsion solvent evaporation method </a> |
| -- | <a href="central composite design [[CCD]">central composite design [[CCD]</a> |
| -- | <a href="Nanosponges [NS]">Nanosponges [NS]</a> |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Amit S. Ghosh |
| 773 0# - HOST ITEM ENTRY | |
| Host Biblionumber | 125265 |
| Host Itemnumber | 114075 |
| Place, publisher, and date of publication | Mumbai Indian Drugs Manufacturer's Association |
| Title | Indian Drugs |
| International Standard Serial Number | 0019-462X |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Koha item type | Journal Article |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Location (home branch) | Sublocation or collection (holding branch) | Date acquired | Koha issues (times borrowed) | Piece designation (barcode) | Koha date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | SNDT Juhu | SNDT Juhu | 03/10/2025 | JP942.1 | 03/10/2025 | 03/10/2025 | Journal Article |