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LIQUISOLID-BASED PULSATILE SYSTEM OF CARVEDILOL: EFFECT OF LIQUISOLID COMPACT ON ANTIHYPERTENSIVE ACTIVITY AND DRUG RELEASE (Record no. 132971)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 01583nam a2200145 4500 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 251003b |||||||| |||| 00| 0 eng d |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Shrikant S. Tapadiaa |
| 245 ## - TITLE STATEMENT | |
| Title | LIQUISOLID-BASED PULSATILE SYSTEM OF CARVEDILOL: EFFECT OF LIQUISOLID COMPACT ON ANTIHYPERTENSIVE ACTIVITY AND DRUG RELEASE |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | Page No. 27-37 |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. biblio.abstract | Current work was aimed to use liquisolid compact technology to build a pulsatile system containing carvedilol. Liquisolid compact based core tablets were produced with a Syloid® 244FP coating and a Neusilin US2® carrier. The tablets were press-coated with a barrier layer made of the polymers hydroxypropyl methylcellulose K 15M and ethyl cellulose. The physical characteristics of the liquisolidbased pulsatile formulations produced were investigated using differential scanning calorimetry, X-ray diffraction analysis and infrared spectroscopic techniques. Compared with a commercial formulation, optimized liquisolid core-tablets reduced the blood pressure significantly (P<0.0001). The lag time of the tablets with the optimized composition was 6 h. The carvedilol release was 100.002% within 2h after the lag time. Our findings suggest that carvedilol was effectively delivered in the desired pulsatile release pattern by the liquisolid compact-based compression-coated tablets. |
| 654 ## - SUBJECT ADDED ENTRY--FACETED TOPICAL TERMS | |
| Subject | <a href="Anthiypertensive ">Anthiypertensive </a> |
| -- | <a href="dissolution ">dissolution </a> |
| -- | <a href="lag time ">lag time </a> |
| -- | <a href="liquisolid ">liquisolid </a> |
| -- | <a href="pulsatile">pulsatile</a> |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Dilesh J. Singhavia |
| 773 0# - HOST ITEM ENTRY | |
| Host Biblionumber | 125265 |
| Host Itemnumber | 114075 |
| Place, publisher, and date of publication | Mumbai Indian Drugs Manufacturer's Association |
| Title | Indian Drugs |
| International Standard Serial Number | 0019-462X |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Koha item type | Journal Article |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Location (home branch) | Sublocation or collection (holding branch) | Date acquired | Koha issues (times borrowed) | Piece designation (barcode) | Koha date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | SNDT Juhu | SNDT Juhu | 03/10/2025 | jp942.2 | 03/10/2025 | 03/10/2025 | Journal Article |